AJIC: American Journal of Infection Control
Volume 35, Issue 7 , Pages 486-488, September 2007

Absence of pharyngeal shedding of vaccinia following smallpox vaccination

  • Thomas R. Talbot, MD, MPH

      Affiliations

    • Division of Infectious Diseases in the Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    • Department of Preventive Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee
    • Corresponding Author InformationAddress correspondence to Thomas R. Talbot, MD, MPH, A-2200 Medical Center North, 1161 21st Avenue South, Vanderbilt University Medical Center, Nashville, TN 37232.
    • ,
  • Jody Peters, BS

      Affiliations

    • Division of Infectious Diseases in the Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
    • ,
  • Peter F. Wright, MD

      Affiliations

    • Division of Infectious Diseases in the Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
    • ,
  • Kathryn M. Edwards, MD

      Affiliations

    • Division of Infectious Diseases in the Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee
    • Pediatric Clinical Research Office, Vanderbilt University School of Medicine, Nashville, Tennessee

To examine oral shedding of vaccinia in volunteers who were recently vaccinated against smallpox, pharyngeal swabs were collected for viral culture between days 3 and 5 and days 6 and 8 after vaccination with diluted Sanofi Pasteur smallpox vaccine. From 102 adult volunteers (48 vaccinia-naive, 54 vaccinia-experienced), vaccinia was not detected in any specimen (0/201, 95% confidence interval, 0-1.8), which suggests a lack of oral shedding of vaccinia after immunization. This supports recommendations that individuals who were recently vaccinated against smallpox do not require placement in airborne or droplet precautions.

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 Presented at the 14th Annual Meeting of the Society of Healthcare Epidemiology of America, Philadelphia, PA, April 18, 2004 (Abstract No. 64). Informed consent was obtained from all patients, and human experimentation guidelines of the U.S. Department of Health and Human Services and Vanderbilt University were followed in the conduct of this research. Funding provided by the National Institute of Allergy and Infectious Diseases (NIAID) Division of Microbiology and Infectious Diseases (DMID), contract #N01-AI-25462.

PII: S0196-6553(06)01161-8

doi:10.1016/j.ajic.2006.07.013

AJIC: American Journal of Infection Control
Volume 35, Issue 7 , Pages 486-488, September 2007

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