AJIC: American Journal of Infection Control
Volume 34, Issue 6 , Pages 388-393 , August 2006

Are antiseptic-coated central venous catheters effective in a real-world setting?

  • Debaroti M. Borschel, MD, MS

      Affiliations

    • From the Department of Internal Medicine, University of Michigan
    • Patient Safety Enhancement Program, Ann Arbor VA Medical Center and the University of Michigan Health System
    • Corresponding Author InformationReprint requests: Debaroti M. Borschel, MD, 3116 Taubman Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0376.
    • ,
  • Carol E. Chenoweth, MD

      Affiliations

    • From the Department of Internal Medicine, University of Michigan
    • Department of Infection Control and Epidemiology, University of Michigan
    • ,
  • Samuel R. Kaufman, MA

      Affiliations

    • Patient Safety Enhancement Program, Ann Arbor VA Medical Center and the University of Michigan Health System
    • ,
  • Kristi Vander Hyde, MS, APRN, CIC

      Affiliations

    • Department of Infection Control and Epidemiology, University of Michigan
    • ,
  • Kristen A. VanDerElzen, MPH, CIC

      Affiliations

    • Department of Infection Control and Epidemiology, University of Michigan
    • ,
  • Trivellore E. Raghunathan, PhD

      Affiliations

    • Department of Biostatistics, University of Michigan
    • ,
  • Curtis D. Collins, PharmD, MS

      Affiliations

    • Department of Pharmacy Services, University of Michigan Health System
    • ,
  • Sanjay Saint, MD, MPH

      Affiliations

    • Ann Arbor VA Health Services Research and Development Center of Excellence, Ann Arbor, MI
    • From the Department of Internal Medicine, University of Michigan
    • Patient Safety Enhancement Program, Ann Arbor VA Medical Center and the University of Michigan Health System

References 

  1. National Nosocomial Infections Surveillance (NNIS) System report, Data summary from January 1990-May 1999, issued June 1999. Am J Infect Control. 1999;27:520–532
  2. Mermel LA. Prevention of intravascular catheter-related infections. Ann Intern Med. 2000;132:391–402
  3. Pittet D, Tarara D, Wenzel RP. Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1994;271:1598–1601
  4. Collignon PJ. Intravascular catheter associated sepsis: a common problem. The Australian Study on Intravascular Catheter Associated Sepsis. Med J Aust. 1994;161:374–378
  5. Safdar N, Kluger DM, Maki DG. A review of risk factors for catheter-related bloodstream infection caused by percutaneously inserted, noncuffed central venous catheters: implications for preventive strategies. Medicine (Baltimore). 2002;81:466–479
  6. Saint S, Veenstra DL, Lipsky BA. The clinical and economic consequences of nosocomial central venous catheter-related infection: are antimicrobial catheters useful?. Infect Control Hosp Epidemiol. 2000;21:375–380
  7. Rello J, Ochagavia A, Sabanes E, Roque M, Mariscal D, Reynaga E, et al. Evaluation of outcome of intravenous catheter-related infections in critically ill patients. Am J Respir Crit Care Med. 2000;162:1027–1030
  8. Dimick JB, Pelz RK, Consunji R, Swoboda SM, Hendrix CW, Lipsett PA. Increased resource use associated with catheter-related bloodstream infection in the surgical intensive care unit. Arch Surg. 2001;136:229–234
  9. Veenstra DL, Saint S, Sullivan SD. Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA. 1999;282:554–560
  10. Eyer S, Brummitt C, Crossley K, Siegel R, Cerra F. Catheter-related sepsis: prospective, randomized study of three methods of long-term catheter maintenance. Crit Care Med. 1990;18:1073–1079
  11. Cobb DK, High KP, Sawyer RG, Sable CA, Adams RB, Lindley DA, et al. A controlled trial of scheduled replacement of central venous and pulmonary-artery catheters. N Engl J Med. 1992;327:1062–1068
  12. Nystrom B. Impact of handwashing on mortality in intensive care: examination of the evidence. Infect Control Hosp Epidemiol. 1994;15:435–436
  13. Doebbeling BN, Stanley GL, Sheetz CT, Pfaller MA, Houston AK, Annis L, et al. Comparative efficacy of alternative hand-washing agents in reducing nosocomial infections in intensive care units. N Engl J Med. 1992;327:88–93
  14. Maki DG, Ringer M, Alvarado CJ. Prospective randomised trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet. 1991;338:339–343
  15. Mimoz O, Pieroni L, Lawrence C, Edouard A, Costa Y, Samii K, et al. Prospective, randomized trial of two antiseptic solutions for prevention of central venous or arterial catheter colonization and infection in intensive care unit patients. Crit Care Med. 1996;24:1818–1823
  16. Veenstra DL, Saint S, Saha S, Lumley T, Sullivan SD. Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection: a meta-analysis. JAMA. 1999;281:261–267
  17. Bach A. Clinical studies on the use of antibiotic- and antiseptic-bonded catheters to prevent catheter-related infection. Zentralbl Bakteriol. 1995;283:208–214
  18. Tennenberg S, Lieser M, McCurdy B, Boomer G, Howington E, Newman C, et al. A prospective randomized trial of an antibiotic- and antiseptic-coated central venous catheter in the prevention of catheter-related infections. Arch Surg. 1997;132:1348–1351
  19. Maki DG, Stolz SM, Wheeler S, Mermel LA. Prevention of central venous catheter-related bloodstream infection by use of an antiseptic-impregnated catheter: a randomized, controlled trial. Ann Intern Med. 1997;127:257–266
  20. Logghe C, Van Ossel C, D'Hoore W, Ezzedine H, Wauters G, Haxhe JJ. Evaluation of chlorhexidine and silver-sulfadiazine impregnated central venous catheters for the prevention of bloodstream infection in leukaemic patients: a randomized controlled trial. J Hosp Infect. 1997;37:145–156
  21. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definitions for nosocomial infections, 1988. Am J Infect Control. 1988;16:128–140
  22. Preventing the Spread of Vancomycin Resistance–A Report from the Hospital Infection Control Practices Advisory Committee prepared by the Subcommittee on Prevention and Control of Antimicrobial-Resistant Microorganisms in Hospitals; comment period and public meeting–CDC. Notice. Federal Register. 1994;59:25758–25763
  23. Pauker SG. Deciding about screening. Ann Intern Med. 1993;118:901–902
  24. Digiovine B, Chenoweth C, Watts C, Higgins M. The attributable mortality and costs of primary nosocomial bloodstream infections in the intensive care unit. Am J Respir Crit Care Med. 1999;160:976–981
  25. O'Grady NP, Alexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, et al. Guidelines for the prevention of intravascular catheter-related infections. Centers for Disease Control and Prevention. MMWR Recomm Rep. 2002;51:1–29
  26. Stosor V, Peterson LR, Postelnick M, Noskin GA. Enterococcus faecium bacteremia: does vancomycin resistance make a difference?. Arch Intern Med. 1998;158:522–527
  27. Carmeli Y, Samore MH, Huskins C. The association between antecedent vancomycin treatment and hospital-acquired vancomycin-resistant enterococci: a meta-analysis. Arch Intern Med. 1999;159:2461–2468
  28. Cetinkaya Y, Falk PS, Mayhall CG. Effect of gastrointestinal bleeding and oral medications on acquisition of vancomycin-resistant Enterococcus faecium in hospitalized patients. Clin Infect Dis. 2002;35:935–942
  29. Fridkin SK, Edwards JR, Courval JM, Hill H, Tenover FC, Lawton R, et al. The effect of vancomycin and third-generation cephalosporins on prevalence of vancomycin-resistant enterococci in 126 US adult intensive care units. Ann Intern Med. 2001;135:175–183
  30. D'Agata EM, Green WK, Schulman G, Li H, Tang YW, Schaffner W. Vancomycin-resistant enterococci among chronic hemodialysis patients: a prospective study of acquisition. Clin Infect Dis. 2001;32:23–29
  31. Recommendations for preventing the spread of vancomycin resistance. Recommendations of the Hospital Infection Control Practices Advisory Committee (HICPAC). MMWR Recomm Rep. 1995;44:1–13
  32. Fridkin SK, Edwards JR, Pichette SC, Pryor ER, McGowan JE, Tenover FC, et al. Determinants of vancomycin use in adult intensive care units in 41 United States hospitals. Clin Infect Dis. 1999;28:1119–1125
  33. Raad I, Darouiche R, Dupuis J, Abi-Said D, Gabrielli A, Hachem R, et al. Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections: a randomized, double-blind trial. The Texas Medical Center Catheter Study Group. Ann Intern Med. 1997;127:267–274
  34. Raad I, Darouiche R, Hachem R, Mansouri M, Bodey GP. The broad-spectrum activity and efficacy of catheters coated with minocycline and rifampin. J Infect Dis. 1996;173:418–424
  35. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Chlorhexidine compared with povidone-iodine solution for vascular catheter-site care: a meta-analysis. Ann Intern Med. 2002;136:792–801
  36. Chaiyakunapruk N, Veenstra DL, Lipsky BA, Saint S. Vascular catheter site care: the clinical and economic benefits of chlorhexidine gluconate compared with povidone iodine. Clin Infect Dis. 2003;37:764–771

 Supported, in part, by a Patient Safety Fellowship award provided by C. R. Bard and the Research Foundation for the Prevention of Complications Associated with Health Care and the VA/UM Patient Safety Enhancement Program and by a Career Development Award from the Health Services Research & Development Program of the Department of Veterans Affairs and a Patient Safety Developmental Center Grant from the Agency for Healthcare Research and Quality (P20-HS11540, to S.S.).

PII: S0196-6553(05)00775-3

doi: 10.1016/j.ajic.2005.08.004

AJIC: American Journal of Infection Control
Volume 34, Issue 6 , Pages 388-393 , August 2006

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