AJIC: American Journal of Infection Control
Volume 37, Issue 3 , Pages 204-209 , April 2009

The effect of limiting antimicrobial therapy duration on antimicrobial resistance in the critical care setting

  • Alexandre R. Marra, MD

      Affiliations

    • Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • Corresponding Author InformationAddress correspondence to Alexandre R. Marra, MD, Av. Albert Einstein, 627/701, 5° Andar-Bloco B, São Paulo, Brazil, CEP 05651-901.
    • ,
  • Silvana Maria de Almeida, PharmD

      Affiliations

    • Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Luci Correa, MD

      Affiliations

    • Infection Control Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Moacyr Silva Jr., MD

      Affiliations

    • Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Marinês Dalla Valle Martino, MD

      Affiliations

    • Microbiology Laboratory, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Cláudia Vallone Silva, RN

      Affiliations

    • Infection Control Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Ruy Guilherme Rodrigues Cal, MD

      Affiliations

    • Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil
    • ,
  • Michael B. Edmond, MD, MPH, MPA

      Affiliations

    • Department of Internal Medicine, Virginia Commonwealth University School of Medicine, Richmond, VA
    • ,
  • Oscar Fernando Pavão dos Santos, MD

      Affiliations

    • Intensive Care Unit, Hospital Israelita Albert Einstein, São Paulo, Brazil

References 

  1. American Thoracic Society, Infectious Diseases Society of America . Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia. Am J Respir Crit Care Med. 2005;171:388–416
  2. Deresinski S. Principles of antibiotic therapy in severe infections: optimizing the therapeutic approach by use of laboratory and clinical data. Clin Infect Dis. 2007;45:177–183
  3. Ibrahim EH, Sherman G, Ward S, Fraser VJ, Kollef MH. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118:9–11
  4. Kumar A, Roberts D, Wood KE, Light B, Parrillo JE, Sharma S, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589–1596
  5. Kollef MH. Inadequate antimicrobial treatment: an important determinant of outcome for hospitalized patients. Clin Infect Dis. 2000;31:131–138
  6. Spelberg B, Guidos R, Gilbert D, Bradley J, Boucher HW, Scheld WM, et al. for the Infectious Diseases Society of America The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. Clin Infect Dis. 2008;46:155–164
  7. Levin AS, Barone AA, Penço J, Santos MV, Marinho IS, Arruda EA, et al. Intravenous colistin as therapy for nosocomial infections caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii. Clin Infect Dis. 1999;28:1008–1011
  8. Pimentel JD, Low J, Styles K, Harris OC, Hughes A, Athan E. Control of an outbreak of multi-drug-resistant Acinetobacter baumannii in an intensive care unit and a surgical ward. J Hosp Infect. 2005;59:249–253
  9. Chastre J, Wolff M, Fagon JY, Chevret S, Thomas F, Wermert D, et al. the PneumA Trial Group Comparison of 8 vs. 15 days of antibiotic therapy for ventilator-associated pneumonia in adults: a randomized trial. JAMA. 2003;290:2588–2598
  10. Meyer E, Buttler J, Schneider C, Strehl E, Schroeren-Boersch B, Gastmeier P, et al. Modified guidelines impact on antibiotic use and costs: duration of treatment for pneumonia in a neurosurgical ICU is reduced. J Antimicrob Chemother. 2007;59:1148–1154
  11. Garner JS, Jarvis WR, Emori TB, Horan TC, Hughes JM. CDC definitions for nosocomial infections. Am J Infect Control. 1988;6:128–140
  12. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829
  13. Clinical and Laboratory Standards Institute . Performance standards for antimicrobial susceptibility testing: sixteenth informational supplement. CLSI document M100–S16. Wayne, PA: CLSI; 2006;
  14. National Nosocomial Infectious Surveillance System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control. 2004;32:470–485
  15. Friedrich LV, White RL, Bosso JA. Impact of use of multiple antimicrobials on changes in susceptibility of gram-negatives aerobes. Clin Infect Dis. 1999;28:1017–1024
  16. Rahal JJ, Urban C, Horn D, Freeman K, Segal-Maurer S, Maurer J, et al. Class restriction of cephalosporin use to control total cephalosporin resistance in nosocomial Klebsiella. JAMA. 1998;280:1233–1237
  17. Harris AD, Bradham DD, Baumgarten M, Zuckerman IH, Fink JC, Perencevich EN. The use and interpretation of quasi-experimental studies in infectious diseases. Clin Infect Dis. 2004;38:1586–1591
  18. Aarts MA, Brun-Buisson C, Cook DJ, Kumar A, Opal S, Rocker G, et al. Antibiotic management of suspected nosocomial ICU-acquired infection: does prolonged empiric therapy improve outcome?. Intensive Care Med. 2007;33:1369–1378

PII: S0196-6553(08)00719-0

doi: 10.1016/j.ajic.2008.06.008

AJIC: American Journal of Infection Control
Volume 37, Issue 3 , Pages 204-209 , April 2009

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