AJIC: American Journal of Infection Control
Volume 37, Issue 6 , Pages 442-446 , August 2009

The role of interventional molecular epidemiology in controlling clonal clusters of multidrug resistant Pseudomonas aeruginosa in critically ill cancer patients

References 

  1. Bukholm G, Tannaes T, Kjelsberg AB, Smith-Erichsen N. An outbreak of multidrug-resistant Pseudomonas aeruginosa associated with increased risk of patient death in an intensive care unit. Infect Control Hosp Epidemiol. 2002;23:441–446
  2. Carmeli Y, Triollet N, Karchmer A, Samore MH. Health and economic outcomes of antibiotic resistance in Pseudomonas aeruginosa. Arch Intern Med. 1999;159:1127–1132
  3. Cortes P, Mariscal D, Valles J, Rello J, Coll P. Presence of polyclonal Pseudomonas aeruginosa in an intensive care unit: a 27-month prospective study on molecular epidemiology. Infect Control Hosp Epidemiol. 2001;22:720–723
  4. Gales AC, Jones RN, Turnidge J, Rennie R, Ramphal R. Characterization of Pseudomonas aeruginosa isolates: occurrence rates, antimicrobial susceptibility patterns, and molecular typing in the global SENTRY Antimicrobial Surveillance Program, 1997-1999. Clin Infect Dis. 2001;32(Suppl 2):S146-55
  5. Harris A, Torres-Viera C, Venkataraman L, DeGirolami P, Samore M, Carmei Y. Epidemiology and clinical outcomes of patients with multiresistant Pseudomonas aeruginosa. Clin Infect Dis. 1999;28:1128–1133
  6. Livermore DM. Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?. Clin Infect Dis. 2002;34:634–640
  7. Paterson DL. The epidemiological profile of infections with multidrug-resistant Pseudomonas aeruginosa and Acinetobacter species. Clin Infect Dis. 2006;43(Suppl 2):S43–S48
  8. Talon D, Mulin B, Rouget C, Bailly P, Thouverez M, Viel J-F. Risks and routes for ventilator-associated pneumonia with Pseudomonas aeruginosa. Am J Respir Crit Care Med. 1998;157:978–984
  9. Aloush V, Navon-Venezia S, Seigman-Igra Y, Cabili S, Carmeli Y. Multidrug-resistant Pseudomonas aeruginosa: risk factors and clinical impact. Antimicrob Agent Chemother. 2006;50:43–48
  10. Elting LS, Rubenstein EB, Rolston KV, Bodey GP. Outcomes of bacteremia in patients with cancer and neutropenia: observations from two decades of epidemiological and clinical trials. Clin Infect Dis. 1997;2:247–259
  11. National Nosocomial Infections Surveillance System . National Nosocomial Infections Surveillance System report, data summary from January 1992 to June 2002, issued August 2002. Am J Infect Control. 2002;30:458–475
  12. Ohmagari N, Hanna H, Graviss L, Hackett B, Perego C, Gonzalez V, et al. Risk factors for infections with multidrug-resistant Pseudomonas aeruginosa in patients with cancer. Cancer. 2005;104:205–212
  13. Rossello J, Olona M, Campins M, del Valle O, Bermejo B, Armandans L, et al. Investigation of an outbreak of nosocomial infection due to a multiply drug-resistant strain of Pseudomonas aeruginosa. J Hosp Infect. 1992;20:87–96
  14. Sanders CC, Sanders WE. Beta-lactam resistance in gram-negative bacteria: global trends and clinical impact. Clin Infect Dis. 1992;15:824–839
  15. Bennett JV. Session 1. Hospital-acquired infections and the altered host: nosocomial infections due to Pseudomonas. J Infect Dis. 1974;130(Suppl):S4–S7
  16. Bodey GP, Bolivar R, Fainstein V, Jadeja L. Infections caused by Pseudomonas aeruginosa. Rev Infect Dis. 1983;5:279–313
  17. Whitecar JP, Luna M, Bodey GP. Pseudomonas bacteremia in patients with malignant diseases. Am J Med Sci. 1970;260:216–223
  18. Talbot GH, Bradley J, Edwards JE, Gilbert D, Scheld M, Barlett JG. Bad bugs need drugs: an update on the development pipeline from the Antimicrobial Availability Task Force of the Infectious Diseases Society of America. Clin Infect Dis. 2006;42:657–668
  19. Deplano A, Denis O, Poirel L, Hocquet D, Nonhoff C, Byl B, et al. Molecular characterization of an epidemic clone of panantibiotic-resistant Pseudomonas aeruginosa. J Clin Microbiol. 2005;43:1198–1204
  20. Paterson DL. Looking for risk factors for the acquisition of antibiotic resistance: a 21st-century approach. Clin Infect Dis. 2002;34:1564–1567
  21. Sader H, Pignatari AC, Leme IL, Burattini MN, Tancresi R, Hollis RJ, et al. Epidemiologic typing of multiple drug-resistant Pseudomonas aeruginosa isolated from an outbreak in an intensive care unit. Diagn Microbiol Infect Dis. 1993;17:13–18
  22. Speijer H, Savelkoul PH, Bonten MJ, Stobberingh EE, Tjhie JH. Application of different genotyping methods for Pseudomonas aeruginosa in a setting of endemicity in an intensive care unit. J Clin Microbiol. 1999;37:3654–3661
  23. Talon D, Cailleaux V, Thouverez M, Michel-Briand Y. Discriminatory power and usefulness of pulsed-field gel electrophoresis in epidemiological studies of Pseudomonas aeruginosa. J Hosp Infect. 1996;32:135–145
  24. Garner JS, Jarvis WR, Emori TG, Horan TC, Hughes JM. CDC definition for nosocomial infections. In:  Olmstead RN editors. Infection control and applied epidemiology: principles and practice. St. Louis: Mosby; 1996;
  25. National Committee for Clinical Laboratory Standards (NCCLS), currently the Clinical and Laboratory Standards Institute (CLSI). Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically, 5th ed. Approved standard M7–A5. Wayne: National Committee for Clinical Laboratory Standards; 2002.
  26. Finney M. Pulsed-field gel electrophoresis. In:  Anusubel FM,  Brent R,  Kingston RE,  Moore DD,  Seidman JG,  Smith JA,  Struhl K editor. Current protocols in molecular biology, vol. 1. Current protocols. New York: Greene-Wiley; 1993;2.5.9-2.5.17
  27. Tenover FC, Arbeit RD, Goering RV, Mickelsen PA, Murray BE, Persing DH, et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol. 1995;33:2233–2239
  28. Hocquet D, Bertrand X, Kohler T, Talon D, Plesiat P. Genetic and phenotypic variations of a resistant Pseudomonas aeruginosa epidemic clone. Antimicrob Agent Chemother. 2003;47:1887–1894
  29. Murray SA, Snydman DR. Investigation of an epidemic of multidrug-resistant Pseudomonas aeruginosa. Infect Control. 1982;3:456–460
  30. Paramythiotou E, Lucet JC, Timsit J-F, Vanjack D, Paugam-Burtz C, Trouillet JL, et al. Acquisition of multidrug-resistant Pseudomonas aeruginosa in patients in intensive care units: role of antibiotics with antipseudomonal activity. Clin Infect Dis. 2004;38:670–677
  31. El Amari EB, Chamot E, Auckenthaler R, Pechere JC, Van Delden C. Influence of previous exposure to antibiotic therapy on the susceptibility pattern of Pseudomonas aeruginosa bacteremic isolates. Clin Infect Dis. 2001;33:1859–1864
  32. Rello J, Ausina V, Ricart M, Puzo C, Quintana E, Net A, et al. Risk factors for infection by Pseudomonas aeruginosa in patients with ventilator-associated pneumonia. Intensive Care Med. 1994;20:193–198
  33. Doebbeling BN, Pfaller MA, Houston AK, Wenzel RP. Removal of nosocomial pathogens from the contaminated glove: implications for glove reuse and handwashing. Ann Intern Med. 1988;109:394–398
  34. McNeil SA, Nordstrom-Lerner L, Malani PN, Zervos M, Kauffman CA. Outbreak of sternal surgical site infections due to Pseudomonas aeruginosa traced to a scrub nurse with onychomycosis. Clin Infect Dis. 2001;33:317–323
  35. Moolenaar RL, Crutcher JM, San Joaquin VH, Sewell LV, Hutwagner LC, Carson LA, et al. A prolonged outbreak of Pseudomonas aeruginosa in a neonatal intensive care unit: did staff fingernails play a role in disease transmission?. Infect Control Hosp Epidemiol. 2000;21:80–85
  36. Trautmann M, Michalsky T, Wiedeck H, Radosavljevic V, Ruhnke M. Tap water colonization with Pseudomonas aeruginosa in a surgical intensive care unit (ICU) and relation to Pseudomonas infections of ICU patients. Infect Control Hosp Epidemiol. 2001;22:49–52
  37. Widmer AF, Wenzel RP, Trilla A, Bale MJ, Jones RN, Doebbeling BN. Outbreak of Pseudomonas aeruginosa infections in a surgical intensive care unit: probable transmission via hands of a health care worker. Clin Infect Dis. 1993;16:372–376
  38. Harris AD, McGregor JC, Furuno JP. What infection control interventions should be undertaken to control multidrug-resistant gram-negative bacteria?. Clin Infect Dis. 2006;43(Suppl 2):S57–S61

 The results of this article were presented partially at the 16th Annual Meeting of the Society of Healthcare Epidemiology of America, March 18-21, 2006.

 Supported by discretionary funds, with no external or private financial support.

 Conflicts of interest: None to report.

PII: S0196-6553(08)00763-3

doi: 10.1016/j.ajic.2008.09.012

AJIC: American Journal of Infection Control
Volume 37, Issue 6 , Pages 442-446 , August 2009

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