Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility
published online 25 September 2009.
We explored the association of antibiotic-resistant phenotypes and genotypes in Acinetobacter spp with clinical outcomes and characteristics in 75 patients from a major military treatment facility. Amikacin resistance was associated with nosocomial acquisition of A baumannii, and carbapenem resistance and blaOXA-23 were associated with the need for mechanical ventilation. The presence of blaOXA-23 also correlated with longer hospital and ICU stay. Associations between blaOXA-23 and complexity, duration, and changes made to antibiotic regimens also existed.
aDivision of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH
bResearch Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
cDepartment of Internal Medicine, Walter Reed Army Medical Center, Washington, DC
dDepartments of Pharmacology and Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH
Address correspondence to: Robert A. Bonomo, MD, Section of Infectious Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106.
Supported by the Veterans Affairs Merit Review Program, VISN 10 Geriatric Research Education and Clinical Center, and the National Institutes of Health (RO1 AI072219; to R.A.B.); by a fellowship sponsored by Wyeth Pharmaceuticals (to F.P.); and by the Veterans Affairs Merit Review Program (to C.J.D.).
F.P. and A.M.H. have contributed equally to this work.
Conflicts of interest: None to report. The opinions and assertions contained herein are the authors' alone and do not represent the views of the Walter Reed National Military Medical Center, the US Army, or the Department of Defense.
ABSTRACT