AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 63-65 , February 2010

Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility

  • Federico Perez, MD

      Affiliations

    • Division of Infectious Diseases and HIV Medicine, University Hospitals Case Medical Center, Cleveland, OH
    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • Andrea M. Hujer, BS

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • Edward A. Hulten, MD

      Affiliations

    • Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC
    • ,
  • Joel Fishbain, MD

      Affiliations

    • Department of Internal Medicine, Walter Reed Army Medical Center, Washington, DC
    • ,
  • Kristine M. Hujer, BS

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • David Aron, MD

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • Katherine Thweatt, PhD

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • Curtis J. Donskey, MD

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • ,
  • Robert A. Bonomo, MD

      Affiliations

    • Research Service, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, Cleveland, OH
    • Departments of Pharmacology and Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH
    • Corresponding Author InformationAddress correspondence to: Robert A. Bonomo, MD, Section of Infectious Diseases, Louis Stokes Cleveland Department of Veterans Affairs Medical Center, 10701 East Blvd, Cleveland, OH 44106.

References 

  1. Munoz-Price LS, Weinstein RA. Acinetobacter infection. N Engl J Med. 2008;358:1271–1281
  2. Maragakis LL, Perl TM. Acinetobacter baumannii: epidemiology, antimicrobial resistance, and treatment options. Clin Infect Dis. 2008;46:1254–1263
  3. Lee NY, Lee HC, Ko NY, Chang CM, Shih HI, Wu CJ, et al. Clinical and economic impact of multidrug resistance in nosocomial Acinetobacter baumannii bacteremia. Infect Control Hosp Epidemiol. 2007;28:713–719
  4. Sunenshine RH, Wright MO, Maragakis LL, Harris AD, Song X, Hebden J, et al. Multidrug-resistant Acinetobacter infection mortality rate and length of hospitalization. Emerg Infect Dis. 2007;13:97–103
  5. Kwon KT, Oh WS, Song JH, Chang HH, Jung SI, Kim SW, et al. Impact of imipenem resistance on mortality in patients with Acinetobacter bacteremia. J Antimicrob Chemother. 2007;59:525–530
  6. Peleg AY, Seifert H, Paterson DL. Acinetobacter baumannii: emergence of a successful pathogen. Clin Microbiol Rev. 2008;21:538–582
  7. Scott P, Deye G, Srinivasan A, Murray C, Moran K, Hulten E, et al. An outbreak of multidrug-resistant Acinetobacter baumannii-calcoaceticus complex infection in the US military health care system associated with military operations in Iraq. Clin Infect Dis. 2007;44:1577–1584
  8. Hujer KM, Hujer AM, Hulten EA, Bajaksouzian S, Adams JM, Donskey CJ, et al. Analysis of antibiotic resistance genes in multidrug-resistant Acinetobacter sp isolates from military and civilian patients treated at the Walter Reed Army Medical Center. Antimicrob Agents Chemother. 2006;50:4114–4123
  9. Perez F, Hujer AM, Hujer KM, Decker BK, Rather PN, Bonomo RA. Global challenge of multidrug-resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2007;51:3471–3484

 Supported by the Veterans Affairs Merit Review Program, VISN 10 Geriatric Research Education and Clinical Center, and the National Institutes of Health (RO1 AI072219; to R.A.B.); by a fellowship sponsored by Wyeth Pharmaceuticals (to F.P.); and by the Veterans Affairs Merit Review Program (to C.J.D.).

 F.P. and A.M.H. have contributed equally to this work.

 Conflicts of interest: None to report. The opinions and assertions contained herein are the authors' alone and do not represent the views of the Walter Reed National Military Medical Center, the US Army, or the Department of Defense.

PII: S0196-6553(09)00662-2

doi: 10.1016/j.ajic.2009.05.007

AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 63-65 , February 2010

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