AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 66-68, February 2010

Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization

  • Jochen Steinmann, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • Corresponding Author InformationAddress correspondence to Dr Jochen Steinmann, MikroLab GmbH, Norderoog 2, D-28259 Bremen, Germany.
    • ,
  • Britta Becker, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Birte Bischoff

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Dajana Paulmann, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Martina Friesland

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany
    • ,
  • Thomas Pietschmann, PhD

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany
    • ,
  • Jörg Steinmann, MD, PhD

      Affiliations

    • Institute of Medical Microbiology, Essen University Hospital, Essen, Germany
    • ,
  • Eike Steinmann, PhD

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany

published online 09 November 2009.

The virucidal activity of 2 hand rubs proposed by the World Health Organization was studied in a quantitative suspension test for chemical disinfectants and antiseptics in human medicine (EN 14476). These formulations are recommended if no hand rubs with declared microbiological activity are available in health care settings. Formulation I, based on ethanol, inactivated bovine viral diarrhea virus (BVDV), hepatitis C virus (HCV), adenovirus, and murine norovirus as a surrogate for human norovirus. Formulation II, based on isopropyl alcohol, was active only against adenovirus and enveloped viruses, such as BVDV and HCV. Both formulations failed to inactivate poliovirus by 4log10 steps within 300 seconds.

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PII: S0196-6553(09)00833-5

doi:10.1016/j.ajic.2009.07.009

AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 66-68, February 2010

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