AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 66-68 , February 2010

Virucidal activity of 2 alcohol-based formulations proposed as hand rubs by the World Health Organization

  • Jochen Steinmann, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • Corresponding Author InformationAddress correspondence to Dr Jochen Steinmann, MikroLab GmbH, Norderoog 2, D-28259 Bremen, Germany.
    • ,
  • Britta Becker, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Birte Bischoff

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Dajana Paulmann, PhD

      Affiliations

    • MikroLab GmbH, Bremen, Germany
    • ,
  • Martina Friesland

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany
    • ,
  • Thomas Pietschmann, PhD

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany
    • ,
  • Jörg Steinmann, MD, PhD

      Affiliations

    • Institute of Medical Microbiology, Essen University Hospital, Essen, Germany
    • ,
  • Eike Steinmann, PhD

      Affiliations

    • Division of Experimental Virology, TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover, Germany

References 

  1. Boyce JM, Pittet D. Guideline for hand hygiene in health-care settings: recommendations of the Healthcare Infection Control Practices Advisory Committee and the HICPA/SHEA/APIC/IDSA Hand Hygiene Task Force. MMWR Morb Mortal Wkly Rep. 2002;51:1–45
  2. World Health Organization . WHO Guidelines on Hand Hygiene in Health Care. First Global Patient Safety Challenge: Clean Care is Safer Care. 2009;
  3. EN 14476:2007–02. Chemical disinfectants and antiseptics. Virucidal quantitative suspension test for chemical disinfectants and antiseptics used in human medicine. Test method and requirements (phase 2, step 1); 2007.
  4. Wobus CE, Karst SM, Thackray LB, Chang K-O, Sosnovtsev SV, Belliot G, et al. Replication of norovirus in cell culture reveals a tropism for dendritic cells and macrophages. PLoS Biol. 2004;2:ed432
  5. Wobus CE, Thackray LB, Virgin HW. Murine norovirus: a model system to study norovirus biology and pathogenesis. J Virol. 2006;80:5104–5112
  6. Bartenschlager R, Sparacio S. Hepatitis C virus molecular clones and their replication capacity in vivo and in cell culture. Virus Res. 2007;127:195–207
  7. Kramer A, Galabov AS, Sattar SA, Dohner L, Pivert A, Payan C, et al. Virucidal activity of a new hand disinfectant with reduced ethanol content: comparison with other alcohol-based formulations. J Hosp Infect. 2006;62:98–106
  8. Steinmann J, Becker B, Bischoff B, Paulmann D, Steinmann E. Effectiveness of alcohols, hand rubs and scrubs against murine norovirus: a surrogate of human norovirus. Am J Infect Control. 2009;37:E21–E22
  9. Belliot G, Lavaux A, Souihel D, Agnello D, Pothier P. Use of murine norovirus as a surrogate to evaluate resistance of human norovirus to disinfectants. Appl Environ Microbiol. 2008;74:3315–3318
  10. ASTM E1838-02. Standard test method for determining the virus-eliminating effectiveness of liquid hygienic handwash and handrub agents using the fingerpads of adult volunteers.

PII: S0196-6553(09)00833-5

doi: 10.1016/j.ajic.2009.07.009

AJIC: American Journal of Infection Control
Volume 38, Issue 1 , Pages 66-68 , February 2010

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