AJIC: American Journal of Infection Control
Volume 38, Issue 3 , Pages 212-216 , April 2010

Antibiotic consumption as a driver for resistance in Staphylococcus aureus and Escherichia coli within a developing region

  • Michael A. Borg, MD, PhD

      Affiliations

    • Infection Control Unit, Mater Dei Hospital, Msida, Malta
    • Corresponding Author InformationAddress correspondence to Dr Michael A Borg, Mater Dei Hospital, Infection Control Unit, Msida, Malta.
    • ,
  • Peter Zarb, MPhil

      Affiliations

    • Infection Control Unit, Mater Dei Hospital, Msida, Malta
    • ,
  • Elizabeth A. Scicluna, MSc

      Affiliations

    • Infection Control Unit, Mater Dei Hospital, Msida, Malta
    • ,
  • Ossama Rasslan, PhD

      Affiliations

    • Infectious Disease Research and Infection Control Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt
    • ,
  • Deniz Gür, PhD

      Affiliations

    • Clinical Microbiology Laboratory, Hacettepe University, Ankara, Turkey
    • ,
  • Saida Ben Redjeb, PhD

      Affiliations

    • Microbiology Laboratory, Hospital Charles Nicolle, Tunis, Tunisia
    • ,
  • Ziad Elnasser, MD

      Affiliations

    • Pathology and Microbiology Department, Jordan University of Science and Technology, Irbid, Jordan
    • ,
  • Ziad Daoud, PhD

      Affiliations

    • Microbiology Laboratory, St George University Hospital, Beirut, Lebanon

References 

  1. Borg MA, de Kraker M, Scicluna E, van de Sande-Bruinsma N, Tiemersma E, Monen J, et al. Prevalence of meticillin-resistant Staphylococcus aureus (MRSA) in invasive isolates from southern and eastern Mediterranean countries. J Antimicrob Chemother. 2007;60:1310–1315
  2. Borg MA, van de Sande-Bruinsma N, Scicluna E, de Kraker M, Tiemersma E, Monen J, et al. Antimicrobial resistance in invasive strains of Escherichia coli from southern and eastern Mediterranean laboratories. Clin Microbiol Infect. 2008;14:789–796
  3. Borg MA, Zarb P, Ferech M, Goossens H. ARMed Project Group. Antibiotic consumption in southern and eastern Mediterranean hospitals: results from the ARMed project. J Antimicrob Chemother. 2008;62:830–836
  4. Monnet DL. Methicillin-resistant Staphylococcus aureus and its relationship to antimicrobial use: possible implications for control. Infect Control Hosp Epidemiol1998;19:552–559.
  5. Tacconelli E, De Angelis G, Cataldo MA, Pozzi E, Cauda R. Does antibiotic exposure increase the risk of meticillin-resistant Staphylococcus aureus (MRSA) isolation? A systematic review and meta-analysis. J Antimicrob Chemother. 2008;61:26–38
  6. Muller A, Mauny F, Talon D, Donnan PT, Harbarth S, Bertrand X. Effect of individual- and group-level antibiotic exposure on MRSA isolation: a multilevel analysis. J Antimicrob Chemother. 2006;58:878–881
  7. Archer GL, Armstrong BC. Alteration of staphylococcal flora in cardiac surgery patients receiving antibiotic prophylaxis. J Infect Dis. 1983;147:642–649
  8. Monsen T, Rönnmark M, Olofsson C, Wiström J. Antibiotic susceptibility of staphylococci isolated in blood cultures in relation to antibiotic consumption in hospital wards. Scand J Infect Dis. 1999;31:399–404
  9. Crowcroft NS, Ronveaux O, Monnet DL, Mertens R. Methicillin-resistant Staphylococcus aureus and antimicrobial use in Belgian hospitals. Infect Control Hosp Epidemiol. 1999;20:31–36
  10. Meyer E, Schwab F, Gastmeier P, Rueden H, Daschner FD. Surveillance of antimicrobial use and antimicrobial resistance in German intensive care units (SARI): a summary of the data from 2001 through 2004. Infection. 2006;34:303–309
  11. Graffunder EM, Venezia RA. Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. J Antimicrob Chemother. 2002;49:999–1005
  12. Zaoutis TE, Goyal M, Chu JH, Coffin SE, Bell LM, Nachamkin I, et al. Risk factors for and outcomes of bloodstream infection caused by extended-spectrum beta-lactamase-producing Escherichia coli and Klebsiella species in children. Pediatrics. 2005;115:942–949
  13. Borg MA, Cookson BD, Rasslan O, Gür D, Ben Redjeb S, Benbachir M, et al. Correlation between MRSA prevalence and infection control initiatives within southern and eastern Mediterranean hospitals participating in the ARMed project. J Hosp Infect. 2009;71:36–42
  14. Aldeyab MA, Monnet DL, López-Lozano JM, Hughes CM, Scott MG, Kearney MP, et al. Modeling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant Staphylococcus aureus: a time-series analysis. J Antimicrob Chemother. 2008;62:593–600
  15. Tacconelli E. Antimicrobial use: risk driver of multidrug resistant microorganisms in healthcare settings. Curr Opin Infect Dis. 2009;22:352–358
  16. Borg MA, Cookson BD, Gür D, Ben Rejeb S, Rasslan O, Elnassar Z, et al. Infection control and antibiotic stewardship practices reported by southeastern Mediterranean hospitals collaborating in the ARMed project. J Hosp Infect. 2008;70:228–234

 This study was undertaken as part of the ARMed (Antibiotic Resistance Surveillance and Control in the Mediterranean Region) project, which was funded by the European Commission under the INCOMED program of the DG Research Fifth Framework Protocol (ICA3-CT-2002-10015).

PII: S0196-6553(09)00834-7

doi: 10.1016/j.ajic.2009.07.010

AJIC: American Journal of Infection Control
Volume 38, Issue 3 , Pages 212-216 , April 2010

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