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Influenza A/Philippines/2/82 outbreak in a nursing home: Limitations of influenza vaccination in the aged

  • Julio C. Arroyo
    Correspondence
    Reprint requests: Julio C. Arroyo, M.D., Medical Service, WJB Dorn Veterans Administration Hospital, Columbia, SC 29201.
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
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  • B. Postic
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Search for articles by this author
  • Arnold Brown
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
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  • Kathy Harrison
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
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  • Robert Birgenheier
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Search for articles by this author
  • Harold Dowda
    Affiliations
    From William Jennings Bryan Dorn Veterans Administration Hospital, Department of Health and Environmental Control, Columbia, South Carolina, USA

    Department of Medicine, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Search for articles by this author
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      Abstract

      The failure of the 1982–1983 influenza vaccine to protect elderly NHCU residents from clinical infection with influenza A/Philippines/2/82 resulted primarily from antigenic drift of the epidemic strain, inasmuch as the attack rates in the vaccinated and nonvaccinated patients were not significantly different. This experience supports the decision to replace A/Bangkok/1/79 with A/Philippines/2/82 virus antigen in the 1983–1984 influenza vaccine.10
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