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Hydrogen peroxide vapor room disinfection and hand hygiene improvements reduce Clostridium difficile infection, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and extended-spectrum β-lactamase

      Highlights

      • We implemented hydrogen peroxide vapor for terminal room disinfection of select patient rooms.
      • We concurrently documented improvements in hand hygiene compliance.
      • We report a statistically significant reduction in Clostridium difficile infection, vancomycin-resistant enterococci, and extended-spectrum β-lactamase–producing gram-negative bacteria.
      • Our findings suggest that improvement in environmental and hand hygiene reduce multidrug-resistant organism transmission.
      We report a statistically significant reduction in Clostridium difficile infection (from 1.38 to 0.90 cases per 1,000 patient days), vancomycin-resistant enterococci (from 0.21 to 0.01 cases per 1,000 patient days), and extended-spectrum β-lactamase–producing gram-negative bacteria (from 0.16 to 0.01 cases per 1,000 patient days) associated with the introduction of hydrogen peroxide vapor for terminal decontamination of patient rooms and improvements in hand hygiene compliance.

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