Are short training sessions on hand hygiene effective in preventing hospital-acquired MRSA? A time-series analysis

Published:March 15, 2010DOI:
      We tested the impact of short hand hygiene training sessions and bed occupancy rates on the spread of hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) using a multivariate time-series analysis. According to our model, bed occupancy rates within general ward and intensive care unit settings correlated positively with the incidence of hospital-acquired MRSA, whereas alcohol-based hand rub use and MRSA showed a negative correlation. Furthermore, our model shows that 2 hand hygiene campaigns based on short training sessions effected a long-run reduction in the incidence of hospital-acquired MRSA.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Infection Control
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Pittet D.
        • Hugonnet S.
        • Harbarth S.
        • Mourouga P.
        • Sauvan V.
        • Touveneau S.
        • et al.
        Effectiveness of a hospital-wide programme to improve compliance with hand hygiene.
        Lancet. 2000; 356: 1307-1312
        • Borg M.A.
        • Suda D.
        • Scicluna E.
        Time-series analysis of the impact of bed occupancy rates on the incidence of methicillin-resistant Staphylococcus aureus infection in overcrowded general wards.
        Infect Control Hosp Epidemiol. 2008; 29: 496-502
        • Dancer S.J.
        • Coyne M.
        • Speekenbrink A.
        • Samavedam S.
        • Kennedy J.
        • Wallace P.G.M.
        MRSA acquisition in an intensive care unit.
        Am J Infect Control. 2006; 34: 10-17
        • Greene W.H.
        Econometric analysis.
        Prentice Hall, Upper Saddle River, NJ1997
        • Aldeyab M.A.
        • Monnet D.L.
        • Lopez-Lozano J.M.
        • Hughes C.M.
        • Scott M.G.
        • Kearney M.P.
        • et al.
        Modeling the impact of antibiotic use and infection control practices on the incidence of hospital-acquired methicillin-resistant Staphylococcus aureus: a time-series analysis.
        J Antimicrob Chemother. 2008; 62: 593-600
        • Kaier K.
        • Hagist C.
        • Frank U.
        • Conrad A.
        • Meyer E.
        Two time-series analyses of the impact of antibiotic consumption and alcohol-based hand disinfection on the incidences of nosocomial methicillin-resistant Staphylococcus aureus infection and Clostridium difficile infection.
        Infect Control Hosp Epidemiol. 2009; 30: 346-353
        • Vernaz N.
        • Sax H.
        • Pittet D.
        • Bonnabry P.
        • Schrenzel J.
        • Harbarth S.
        Temporal effects of antibiotic use and hand rub consumption on the incidence of MRSA and Clostridium difficile.
        J Antimicrob Chemother. 2008; 62: 601-607
        • Herud T.
        • Nilsen R.M.
        • Svendheim K.
        • Harthug S.
        Association between use of hand hygiene products and rates of health care-associated infections in a large university hospital in Norway.
        Am J Infect Control. 2009; 37: 311-317
        • Kaier K.
        • Frank U.
        • Hagist C.
        • Conrad A.
        • Meyer E.
        The impact of antimicrobial drug consumption and alcohol-based hand rub use on the emergence and spread of extended-spectrum (β)-lactamase-producing strains: a time-series analysis.
        J Antimicrob Chemother. 2009; 63: 609-614
        • Backman C.
        • Zoutman D.E.
        • Marck P.B.
        An integrative review of the current evidence on the relationship between hand hygiene interventions and the incidence of health care-associated infections.
        Am J Infect Control. 2008; 36: 333-348