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Major article| Volume 40, ISSUE 1, P48-50, February 2012

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An unexpected increase in catheter-associated bloodstream infections at a children’s hospital following introduction of the Spiros closed male connector

      Background

      Catheter-associated bloodstream infections (CA-BSIs) are associated with increased morbidity and mortality. Previous investigations have reported outbreaks of CA-BSI temporally associated with the use of needleless connector valves or similar devices.

      Methods

      We observed an unexpected increase in the rate of CA-BSI at our institution during August 2009. We used statistical process control and quality improvement methodology to identify the factor(s) associated with this increased rate of CA-BSI.

      Results

      We reviewed the overall hospital Shewhart U chart for CA-BSI, which indicated special cause variation with an unexpected cluster (6/9; 67%) of CA-BSIs localized to the oncology ward and the bone marrow transplant unit. An event-cause analysis review showed that 5 of these 9 infections were caused by Staphylococcus aureus. We discovered that the Spiros Closed Male Connector (ICU Medical, San Clemente, CA) had been introduced in these 2 units around the same time as the cluster of infections occurred. Based on this information, we discontinued the use of this device, and the CA-BSI rate and distribution of causative microorganisms returned to previous baseline values.

      Conclusion

      This case study highlights the utility of statistical process control in the surveillance and investigation of CA-BSI.

      Key Words

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      References

        • Odetola F.O.
        • Moler F.W.
        • Dechert R.E.
        • VanDerElzen K.
        • Chenoweth C.
        Nosocomial catheter-related bloodstream infections in a pediatric intensive care unit: risk and rates associated with various intravascular technologies.
        Pediatr Crit Care Med. 2003; 4: 432-436
        • Centers for Disease Control and Prevention, Division of Healthcare Quality Promotion
        The National Healthcare Safety Network (NHSN) manual: patient safety component protocol.
        Centers for Disease Control and Prevention, Atlanta [GA]2009
        • Provonost P.
        • Needham D.
        • Berenholtz S.
        • Sinopoli D.
        • Chu H.
        • Cosgrove S.
        • et al.
        An intervention to decrease catheter-related bloodstream infections in the ICU.
        N Engl J Med. 2006; 355: 2725-2732
        • Miller M.R.
        • Griswold M.
        • Harris J.M.
        • Yenokyan G.
        • Huskins W.C.
        • Moss M.
        • et al.
        Decreasing PICU catheter-associated bloodstream infections: NACHRI’s quality transformation efforts.
        Pediatrics. 2010; 125: 206-213
        • Nowak J.E.
        • Brilli R.J.
        • Lake M.R.
        • Sparling K.W.
        • Butcher J.
        • Schulte M.
        • et al.
        Reducing catheter-associated bloodstream infections in the pediatric intensive care unit: business case for quality improvement.
        Pediatr Crit Care Med. 2010; 11: 579-587
        • McKee C.
        • Berkowitz I.
        • Cosgrove S.E.
        • Bradley K.
        • Beers C.
        • Perl T.M.
        • et al.
        Reduction of catheter-associated bloodstream infections in pediatric patients: experimentation and reality.
        Pediatr Crit Care Med. 2008; 9: 40-46
        • Wirtschafter D.D.
        • Pettit J.
        • Kurtin P.
        • Dalsey M.
        • Chance K.
        • Morrow H.W.
        • et al.
        A statewide quality improvement collaborative to reduce neonatal central line‒associated blood stream infections.
        J Perinatol. 2010; 30: 170-181
        • Harrington G.
        • Watson K.
        • Bailey M.
        • Land G.
        • Borrell S.
        • Houston L.
        • et al.
        Reduction in hospital-wide incidence of infection or colonization with methicillin-resistant Staphylococcus aureus with use of antimicrobial hand-hygeine gel and statistical process control charts.
        Infect Control Hosp Epidemiol. 2007; 28: 837-844
        • Curran E.
        • Harper P.
        • Loveday H.
        • Gilmour H.
        • Jones S.
        • Benneyan J.
        • et al.
        Results of a multicentre randomised controlled trial of statistical process control charts and structured diagnostic tools to reduce ward-acquired methicillin-resistant Staphylococcus aureus: the CHART Project.
        J Hosp Infect. 2008; 70: 127-135
        • Thor J.
        • Lundberg J.
        • Ask J.
        • Olsson J.
        • Carli C.
        • Harenstam K.P.
        • et al.
        Application of statistical process control in healthcare improvement: systematic review.
        Qual Saf Health Care. 2007; 16: 387-399
        • O’Grady N.P.
        • Alexander M.
        • Dellinger E.P.
        • Gerberding J.L.
        • Heard S.O.
        • Maki D.G.
        • et al.
        Guidelines for the prevention of intravascular catheter‒related infections.
        Pediatrics. 2002; 110: e51
        • de Jonge R.C.J.
        • Polderman K.H.
        • Gemke R.J.B.J.
        Central venous catheter use in the pediatric patient: mechanical and infectious complications.
        Pediatr Crit Care Med. 2005; 6: 329-339
        • Simon A.
        • Ammann R.A.
        • Bode U.
        • Fleischhack G.
        • Wenchel H.M.
        • Schwamborn D.
        • et al.
        Healthcare-associated infections in pediatric cancer patients: results of a prospective surveillance study from university hositals in Germany and Switzerland.
        BMC Infect Dis. 2008; 8: 70
      1. Department of Health and Human Services, Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health. NIOSH alert: Preventing occupational exposures to antineoplastic and other hazardous drugs in health care settings. Cincinnati [OH]: DHHS (NIOSH) Publication No. 2004 -165; 2004. Available from: http://www.cdc.gov/niosh. Accessed March 17, 2011.

      2. U.S. Pharmacopeia. Guidebook to pharmaceutical compounding - sterile preparations. Rockville [MD]: USP Publication 797; 2008.

        • Rupp M.E.
        • Sholtz L.A.
        • Jourdan D.R.
        • Marion N.D.
        • Tyner L.K.
        • Fey P.D.
        • et al.
        Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve.
        Clin Infect Dis. 2007; 44: 1408-1414
        • Field K.
        • McFarlane C.
        • Cheng A.C.
        • Hughes A.J.
        • Jacobs E.
        • Styles K.
        • et al.
        Incidence of catheter-related bloodstream infection among patients with a needleless, mechanical valve-based intravenous connector in an Australian hematology-oncology unit.
        Infect Control Hosp Epidemiol. 2007; 28: 610-613