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Brief report| Volume 41, ISSUE 4, P373-375, April 2013

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Clinical impact of switching conventional enzyme immunoassay with nucleic acid amplification test for suspected Clostridium difficile-associated diarrhea

Published:October 08, 2012DOI:https://doi.org/10.1016/j.ajic.2012.04.329
      The impact of a new Clostridium difficile nucleic acid amplification test (NAAT) on antibiotic utilization in patients with suspected C difficile infection was assessed. This single-center, cross-sectional study of 270 patients demonstrated that the use of NAAT decreased antibiotic expenditure by reducing prolonged empiric days of therapy in these patients.

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      References

        • Cohen S.
        • Gerding D.
        • Johnson S.
        • Kelly C.
        • Loo V.
        • McDonald C.
        • et al.
        Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA).
        Infect Control Hosp Epidemiol. 2010; 31: 431-455
        • Ticehurst J.
        • Atird D.
        • Dam L.
        • Borek A.
        • Hargrove T.
        • Carroll K.
        Effective detection of toxigenic Clostridium difficile by a two-step algorithm including tests for antigen and cytotoxin.
        J Clin Microbiol. 2006; 44: 1145-1149
        • Stamper P.
        • Alcabasa R.
        • Aird D.
        • Babiker W.
        • Wehrlin J.
        • Ikepama I.
        • et al.
        Comparison of a commercial real-time PCR assay for tcdB detection to a cell culture cytotoxicity assay and toxigenic culture for direct detection of toxin-producing Clostridium difficile in clinical samples.
        J Clin Microbiol. 2009; 47: 373-378
        • Eastwood K.
        • Else P.
        • Charlett A.
        • Wilcox M.
        Comparison of nine commercially available Clostridium difficile toxin detection assays, a real-time PCR assay for C difficile tcdB, and a glutamate dehydrogenase detection assay to cytotoxin testing and cytotoxigenic culture methods.
        J Clin Microbiol. 2009; 47: 3211-3217
        • Terhes G.
        • Urban E.
        • Soki J.
        • Nacsa E.
        • Nagy E.
        Comparison of a rapid molecular method, the BD Gene-Ohm Cdiff assay, to the most frequently used laboratory tests for detection of toxin-producing Clostridium difficile in diarrheal feces.
        J Clin Microbiol. 2009; 47: 3478-3481
        • Tenover F.
        • Novak-Weekley S.
        • Woods C.
        • Peterson L.
        • Thomas D.
        • Schreckenberger P.
        • et al.
        Impact of strain type on detection of toxigenic Clostridium difficile: comparision of molecular diagnostic and enzyme immunoassay approaches.
        J Clin Microbiol. 2010; 48: 3719
        • Novak-Weekly S.
        • Marlowe E.
        • Miller J.
        • Cumpio J.
        • Nomura J.
        • Vance P.
        • et al.
        Clostridium difficile testing in the clinical laboratory by use of multiple testing algorithms.
        J Clin Microbiol. 2010; 48: 889-893
        • Swindells J.
        • Brenwald N.
        • Reading N.
        • Oppenheim B.
        Evaluation of diagnostic tests for Clostridium difficile disease.
        J Clin Microbiol. 2010; 48: 606-860
      1. illumigene. Package insert. Cincinnati [OH]: Meridian Bioscience Inc; 2011.