In a quasiexperimental study conducted to evaluate the impact of a Protective Environment implementation, febrile neutropenia (P = .009), overall mortality (P = .001), and 30-day adjusted mortality (P = .02) were reduced in cancer patients with chemotherapy-induced neutropenia. Our study highlights the potential success of a set of prevention measures mainly designed to reduce invasive environmental fungal infections in allogeneic hematopoietic stem cell transplant patients, in reducing fever and mortality among neutropenic cancer patients.
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Published online: October 26, 2012
Supported by Coordination for the Improvement of Higher Education Personnel (CAPES) and Research Incentive Fund (FIPE) of the Hospital de Clínicas de Porto Alegre, Brazil.
Conflicts of interest: None to report.
© 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.