In a quasiexperimental study conducted to evaluate the impact of a Protective Environment
implementation, febrile neutropenia (P = .009), overall mortality (P = .001), and 30-day adjusted mortality (P = .02) were reduced in cancer patients with chemotherapy-induced neutropenia. Our
study highlights the potential success of a set of prevention measures mainly designed
to reduce invasive environmental fungal infections in allogeneic hematopoietic stem
cell transplant patients, in reducing fever and mortality among neutropenic cancer
patients.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Infection ControlAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Prevention of hospital-acquired infections: review of non-pharmacological interventions.J Hosp Infect. 2008; 69: 204-219
- 2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings.Am J Infect Control. 2007; 35: 65-164
- Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis.Lancet Infect Dis. 2009; 9: 97-107
- Compliance with a critical pathway for the management of febrile neutropenia and impact on clinical outcomes.Ann Hematol. 2008; 87: 139-145
- The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients.J Clin Oncol. 2000; 18: 3038-3051
- Fungal infections after haematology unit renovation: evidence of clinical, environmental and economical impact.Eur J Haematol. 2008; 80: 436-443
- Effectiveness of preventive measures for hemato-oncologic patients undergoing stem cell transplantation during a period of hospital construction.Am J Infect Control. 2011; 39: 746-751
- Multicenter intervention program to increase adherence to hand hygiene recommendations and glove use and to reduce the incidence of antimicrobial resistance.Infect Control Hosp Epidemiol. 2007; 28: 42-49
- Risk of bacteraemia and mortality in patients with haematological malignancies.Clin Microbiol Infect. 2006; 12: 217-223
- The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.Haematologica. 2006; 91: 1068-1075
Article info
Publication history
Published online: October 26, 2012
Footnotes
Supported by Coordination for the Improvement of Higher Education Personnel (CAPES) and Research Incentive Fund (FIPE) of the Hospital de Clínicas de Porto Alegre, Brazil.
Conflicts of interest: None to report.
Identification
Copyright
© 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.