Brief report| Volume 41, ISSUE 4, P357-359, April 2013

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Effectiveness of a Protective Environment implementation for cancer patients with chemotherapy-induced neutropenia on fever and mortality incidence

Published:October 26, 2012DOI:
      In a quasiexperimental study conducted to evaluate the impact of a Protective Environment implementation, febrile neutropenia (P = .009), overall mortality (P = .001), and 30-day adjusted mortality (P = .02) were reduced in cancer patients with chemotherapy-induced neutropenia. Our study highlights the potential success of a set of prevention measures mainly designed to reduce invasive environmental fungal infections in allogeneic hematopoietic stem cell transplant patients, in reducing fever and mortality among neutropenic cancer patients.

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        • Curtis L.T.
        Prevention of hospital-acquired infections: review of non-pharmacological interventions.
        J Hosp Infect. 2008; 69: 204-219
        • Siegel J.D.
        • Rhinehart E.
        • Jackson M.
        • Chiarello L.
        2007 Guideline for isolation precautions: preventing transmission of infectious agents in health care settings.
        Am J Infect Control. 2007; 35: 65-164
        • Schlesinger A.
        • Paul M.
        • Gafter-Gvili A.
        • Rubinovitch B.
        • Leibovici L.
        Infection-control interventions for cancer patients after chemotherapy: a systematic review and meta-analysis.
        Lancet Infect Dis. 2009; 9: 97-107
        • Zuckermann J.
        • Moreira L.B.
        • Stoll P.
        • Moreira L.M.
        • Kuchenbecker R.S.
        • Polanczyk C.A.
        Compliance with a critical pathway for the management of febrile neutropenia and impact on clinical outcomes.
        Ann Hematol. 2008; 87: 139-145
        • Klastersky J.
        • Paesmans M.
        • Rubenstein E.B.
        • Boyer M.
        • Elting L.
        • Feld R.
        • et al.
        The Multinational Association for Supportive Care in Cancer risk index: a multinational scoring system for identifying low-risk febrile neutropenic cancer patients.
        J Clin Oncol. 2000; 18: 3038-3051
        • Araujo R.
        • Carneiro A.
        • Costa-Oliveira S.
        • Pina-Vaz C.
        • Rodrigues A.G.
        • Guimaraes J.E.
        Fungal infections after haematology unit renovation: evidence of clinical, environmental and economical impact.
        Eur J Haematol. 2008; 80: 436-443
        • Berger J.
        • Willinger B.
        • Diab-Elschahawi M.
        • Blacky A.
        • Kalhs P.
        • Koller W.
        • et al.
        Effectiveness of preventive measures for hemato-oncologic patients undergoing stem cell transplantation during a period of hospital construction.
        Am J Infect Control. 2011; 39: 746-751
        • Trick W.E.
        • Vernon M.O.
        • Welbel S.F.
        • Demarais P.
        • Hayden M.K.
        • Weinstein R.A.
        Multicenter intervention program to increase adherence to hand hygiene recommendations and glove use and to reduce the incidence of antimicrobial resistance.
        Infect Control Hosp Epidemiol. 2007; 28: 42-49
        • Norgaard M.
        • Larsson H.
        • Pedersen G.
        • Schonheyder H.C.
        • Sorensen H.T.
        Risk of bacteraemia and mortality in patients with haematological malignancies.
        Clin Microbiol Infect. 2006; 12: 217-223
        • Pagano L.
        • Caira M.
        • Candoni A.
        • Offidani M.
        • Fianchi L.
        • Martino B.
        • et al.
        The epidemiology of fungal infections in patients with hematologic malignancies: the SEIFEM-2004 study.
        Haematologica. 2006; 91: 1068-1075