Background
Pseudomonas aeruginosa and Acinetobacter species frequently cause intrahospital urinary tract infections (IUTI), contributing
to increased hospital morbidity and mortality. Our objective was further exploration
of possible risk factors for development of IUTI caused by P aeruginosa and Acinetobacter spp, including their resistance to various antibiotics.
Methods
The prospective case control study was conducted in Clinical Center Kragujevac, Serbia,
during the period January 2009 to December 2011 and covered all patients with IUTI
according to the Centers for Disease Control and Prevention criteria. The patients
classified as “cases” had an IUTI caused by P aeruginosa or Acinetobacter spp. The control patients were matched to the cases and selected randomly from the
remaining patients.
Results
There were 79 cases (11.9%) and 586 (88.1%) controls in the study. According to the
multivariate binary logistic regression, there were 3 significant predictors of P aeruginosa and Acinetobacter spp IUTI: male sex (odds ratio [OR], 0.423; 95% confidence interval [CI]: 0.251-0.711;
P = .001), stay in another hospital ward before emergence of IUTI (OR, 1.704; 95% CI:
1.013-2.864; P = .044), and previous use of penicillins and their combinations with inhibitors of
β-lactamases (OR, 2.643; 95% CI: 1.044-6.692; P = .040).
Conclusion
Knowing that IUTI caused by above-mentioned bacteria are especially frequent among
male patients, after previous use of penicillins, and in patients who spent some time
previously at other wards, sound strategies for prevention of such infections in clinical
practice should be developed.
Key Words
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Article info
Publication history
Published online: May 31, 2013
Footnotes
Supported in part by grant No. 175007 from the Serbian Ministry of Education and by a grant from the Ministry of Science of Montenegro.
Conflicts of interest: None to report.
Identification
Copyright
© 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
