Background
Surgical site infections (SSIs) are common complications after surgeries, usually
leading to increased health care costs. Therefore, we evaluated the efficiency of
current preoperative antibiotic prophylaxis and risk factors of SSIs in the orthopedic
wards in a major teaching hospital in China.
Methods
We retrospectively reviewed a population of 2,061 patients who underwent orthopedic
surgeries between January 2010 and January 2012 and examined the bacterial isolates
and their resistance patterns associated with orthopedic infections. Moreover, a multivariate
logistic regression was used to identify independent risk factors for SSIs.
Results
Thirty-three out of the 45 clinical SSIs were culture positive, and a total of 35
bacterial strains was isolated, among which, 65.72% (n = 23) were gram-positive isolates,
and 34.28% (n = 12) were gram-negative bacteria. Significantly, 68.6% of all bacterial
isolates were resistant to cefuroxime. Additionally, this study found that diabetes
mellitus (odds ratio [OR], 7.539), smoking (OR, 2.378), duration of surgeries longer
than 3 hours (OR, 3.633), absence of antibiotic prophylaxis (OR, 6.562), and previous
operations (OR, 2.190) were crucial independent risk factors associated with a significant
increase in the development rate of SSIs following orthopedic incisional operations.
Conclusion
Our data suggested that appropriate modifications to antibiotic prophylaxis regimens
should be considered. Furthermore, tightening glucose control, stopping smoking, providing
proper antibiotic prophylaxis, and shortening surgery time are promising approaches
to reduce the SSIs rate.
Key Words
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Article info
Publication history
Published online: July 29, 2013
Footnotes
Conflicts of interest: None to report.
Identification
Copyright
© 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
