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Decreased duration of acute upper respiratory tract infections with daily intake of fermented milk: A multicenter, double-blinded, randomized comparative study in users of day care facilities for the elderly population

      Background

      There is insufficient evidence of preventive effect of probiotics on upper respiratory tract infections (URTIs) in an elderly population.

      Methods

      We conducted a multicenter, double-blinded, randomized, placebo-controlled parallel group study. Elderly persons had participated who used day care at 4 facilities in Tokyo. We used fermented milks containing Lactobacillus casei strain Shirota (LcS) and placebo drinks as test drinks.

      Results

      A total of 154 subjects was analyzed. The number of persons diagnosed with an acute URTIs was almost identical in both groups (LcS: 31, placebo: 32), whereas the number of acute URTIs events (LcS: 68, placebo: 51) and the symptom score (LcS: 425, placebo: 396) were both higher in the LcS group. Permutation tests performed using the total number of acute URTIs infection events/total days of observation and the total symptom score/total days of observation found no statistically significant difference respectively (P values of .89 and .64, respectively). Comparing the mean duration of infection per infection event found a shorter mean duration in the LcS group (LcS: 3.71 days, placebo: 5.40 days), and the difference was statistically significant.

      Conclusion

      The results suggest that fermented milk containing LcS probably reduces the duration of acute URTIs.

      Key Words

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      References

        • Jefferson T.
        • Del Mar C.
        • Dooley L.
        • Ferroni E.
        • Al-Ansary L.A.
        • Bawazeer G.A.
        • et al.
        Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review.
        BMJ. 2009; 339: b3675
        • Bloomfield S.F.
        • Aiello A.E.
        • Cookson B.
        • O’Boyle C.
        • Larson E.L.
        The effectiveness of hand hygiene procedures in reducing the risks of infections in home and community settings including hand washing and alcohol-based hand sanitizers.
        Am J Infect Control. 2007; 35: S27-S64
        • Brown S.M.
        • Lubimova A.V.
        • Khrustalyeva N.M.
        • Shulaeva S.V.
        • Tekhova I.
        • Zueva L.P.
        • et al.
        Use of an alcohol-based hand rub and quality improvement interventions to improve hand hygiene in a Russian neonatal intensive care unit.
        Infect Control Hosp Epidemiol. 2003; 24: 172-179
        • Eckmanns T.
        • Bessert J.
        • Behnke M.
        • Gastmeier P.
        • Ruden H.
        Compliance with antiseptic hand rub use in intensive care units: the Hawthorne effect.
        Infect Control Hosp Epidemiol. 2006; 27: 931-934
        • Barbut F.
        • Maury E.
        • Goldwirt L.
        • Boelle P.Y.
        • Neyme D.
        • Aman R.
        • et al.
        Comparison of the antibacterial efficacy and acceptability of an alcohol-based hand rinse with two alcohol-based hand gels during routine patient care.
        J Hosp Infect. 2007; 66: 167-173
        • Traore O.
        • Hugonnet S.
        • Lübbe J.
        • Griffiths W.
        • Pittet D.
        Liquid versus gel handrub formulation: a prospective intervention study.
        Crit Care. 2007; 11: R52
        • Takahashi I.
        • Osaki Y.
        • Okamoto M.
        • Tahara A.
        • Kishimoto T.
        The current status of hand washing and glove use among care staff in Japan: its association with the education, knowledge, and attitudes of staff, and infection control by facilities.
        Environ Health Prev Med. 2009; 14: 336-344
        • Hübner N.O.
        • Hübner C.
        • Kramer A.
        Impact of health campaign on hand hygiene with alcohol-based hand rubs in a non-clinical setting.
        J Hosp Infect. 2013; 83: S23-S28
        • Takahashi I.
        • Turale S.
        Evaluation of individual and facility factors that promote hand washing in aged-care facilities in Japan.
        Nurs Health Sci. 2010; 12: 127-134
        • Hatakka K.
        • Savilahti E.
        • Pönkä A.
        • Meurman J.H.
        • Poussa T.
        • Nase L.
        • et al.
        Effect of long term consumption of probiotic milk on infections in children attending day care centres: double-blind, randomised trial.
        BMJ. 2001; 322: 1-5
        • Tamura M.
        • Shikina T.
        • Morihana T.
        • Hayama M.
        • Kajimoto O.
        • Sakamoto A.
        • et al.
        Effects of probiotics on allergic rhinitis induced by Japanese cedar pollen: randomized double-blind placebo-controlled clinical trial.
        Int Arch Allergy Immunol. 2007; 143: 75-82
        • Aso Y.
        • Akaza H.
        • Kotake T.
        • Tsukamoto T.
        • Imai K.
        • Naito S.
        Preventive effect of a Lactobacillus casei preparation on the recurrence of superficial bladder cancer in a double-blind trial. The BLP Study Group.
        Eur Urol. 1995; 27: 104-109
        • Oelschlaeger T.A.
        Mechanisms of probiotic actions: a review.
        Int J Med Microbiol. 2010; 300: 57-62
        • de Vrese M.
        • Winkler P.
        • Rautenberg P.
        • Harder T.
        • Noah C.
        • Laue C.
        • et al.
        Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial.
        Vaccine. 2006; 24: 6670-6674
        • Olivares M.
        • Díaz-Ropero M.P.
        • Sierra S.
        • Lara-Villoslada F.
        • Fonolla J.
        • Navas M.
        • et al.
        Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination.
        Nutrition. 2007; 23: 254-260
        • Boge T.
        • Rémigy M.
        • Vaudaine S.
        • Tanguy J.
        • Bourdet-Sicard R.
        • van der Werf S.
        A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials.
        Vaccine. 2009; 27: 5677-5684
        • Nanno M.
        • Kato I.
        • Kobayashi T.
        • Shida K.
        Biological effects of probiotics: what impact does Lactobacillus casei Shirota have on us?.
        Int J Immunopathol Pharmacol. 2011; 24: S45-S50
        • Dong H.
        • Rowland I.
        • Yaqoob P.
        Comparative effects of six probiotic strains on immune function in vitro.
        Br J Nutr. 2012; 108: 459-470
        • Lo Curto A.
        • Pitino I.
        • Mandalari G.
        • Dainty J.R.
        • Faulks R.M.
        • John Wickham M.S.
        Survival of probiotic lactobacilli in the upper gastrointestinal tract using an in vitro gastric model of digestion.
        Food Microbiol. 2011; 28: 1359-1366
        • Reale M.
        • Boscolo P.
        • Bellante V.
        • Tarantelli C.
        • Di Nicola M.
        • Forcella L.
        • et al.
        Daily intake of Lactobacillus casei Shirota increases natural killer cell activity in smokers.
        Br J Nutr. 2012; 108: 308-314
        • Shida K.
        • Suzuki T.
        • Kiyoshima-Shibata J.
        • Shimada S.
        • Nanno M.
        Essential roles of monocytes in stimulating human peripheral blood mononuclear cells with Lactobacillus casei to produce cytokines and augment natural killer cell activity.
        Clin Vaccine Immunol. 2006; 13: 997-1003
        • Dong H.
        • Rowland I.
        • Tuohy K.M.
        • Thomas L.V.
        Yaqoob P. Selective effects of Lactobacillus casei Shirota on T cell activation, natural killer cell activity and cytokine production.
        Clin Exp Immunol. 2010; 161: 378-388
        • Nagata S.
        • Asahara T.
        • Ohta T.
        • Yamada T.
        • Kondo S.
        • Bian L.
        • et al.
        Effect of the continuous intake of probiotic-fermented milk containing Lactobacillus casei strain Shirota on fever in a mass outbreak of norovirus gastroenteritis and the faecal microflora in a health service facility for the aged.
        Br J Nutr. 2011; 106: 549-556
        • Yasui H.
        • Kiyoshima J.
        • Hori T.
        Reduction of Influenza virus titer and protection against influenza virus infection in infant mice fed Lactobacillus casei Shirota.
        Clin Diagn Lab Immunol. 2004; 11: 675-679
        • Hori T.
        • Kiyoshima J.
        • Shida K.
        • Yasui H.
        Augmentation of cellular immunity and reduction of influenza virus titer in aged mice fed Lactobacillus casei strain Shirota.
        Clin Diagn Lab Immunol. 2002; 9: 105-108
        • Hori T.
        • Kiyoshima J.
        • Shida K.
        • Yasui H.
        Effect of intranasal administration of Lactobacillus casei Shirota on influenza virus infection of upper respiratory tract in mice.
        Clin Diagn Lab Immunol. 2001; 8: 593-597
        • Jefferson T.
        • Foxlee R.
        • Del Mar C.
        • Dooley L.
        • Ferroni E.
        • Hewak B.
        • et al.
        Physical interventions to interrupt or reduce the spread of respiratory viruses: systematic review.
        BMJ. 2008; 336: 77-80
        • Mossad S.
        • Macknin M.
        • Medendorp S.V.
        • Mason P.
        Zinc gluconate lozenges for treating the common cold: a randomised, double-blind, control-controlled study.
        Ann Intern Med. 1996; 125: 81-88
        • Stansfield S.K.
        • Pierre-Louis M.
        • Lerebours G.
        • Augustin A.
        Vitamin A supplementation and increased prevalence of childhood diarrhoea and acute respiratory infections.
        Lancet. 1993; 342: 578-582
        • de Vrese M.
        • Winkler P.
        • Rautenberg P.
        • Harder T.
        • Noah C.
        • Laue C.
        • et al.
        Effect of Lactobacillus gasseri PA 16/8, Bifidobacterium longum SP 07/3, B bifidum MF 20/5 on common cold episodes: a double-blind, randomized, controlled trial.
        Clin Nutr. 2005; 24: 481-491
        • Garcia-Peñarrubia P.
        • Koster F.T.
        • Kelley R.O.
        • McDowell T.D.
        • Bankhurst A.D.
        Antibacterial activity of human natural-killer cells.
        J Exp Med. 1989; 169: 99-113