Veterans Affairs methicillin-resistant Staphylococcus aureus prevention initiative associated with a sustained reduction in transmissions and health care-associated infections

      Implementation of a methicillin-resistant Staphylococcus aureus (MRSA) Prevention Initiative was associated with significant declines in MRSA transmission and MRSA health care-associated infection rates in Veterans Affairs acute care facilities nationwide in the 33-month period from October 2007 through June 2010. Here, we show continuing declines in MRSA transmissions (P = .004 for trend, Poisson regression) and MRSA health care-associated infections (P < .001) from July 2010 through June 2012. The Veterans Affairs Initiative was associated with these effects, sustained over 57 months, in a large national health care system.

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        • Jain R.
        • Kralovic S.M.
        • Evans M.E.
        • Ambrose M.
        • Simbartl L.A.
        • Obrosky D.S.
        • et al.
        Veterans Affairs initiative to prevent methicillin-resistant Staphylococcus aureus infections.
        N Engl J Med. 2011; 364: 1419-1430
        • Kralovic S.M.
        • Evans M.E.
        • Simbartl L.A.
        • Ambrose M.
        • Jain R.
        • Roselle G.A.
        Zeroing in on methicillin-resistant Staphylococcus aureus: US Department of Veterans Affairs' MRSA Prevention Initiative.
        Am J Infect Control. 2013; 41: 456-458
        • Kallen A.J.
        • Mu Y.
        • Bulens S.
        • Reingold A.
        • Petit S.
        • Gershman K.
        • et al.
        Health care-associated invasive MRSA infections, 2005-2008.
        JAMA. 2010; 304: 641-648
        • Landrum M.L.
        • Neumann C.
        • Cook C.
        • Chukwuma U.
        • Ellis M.W.
        • Hospenthal D.R.
        • et al.
        Epidemiology of Staphylococcus aureus blood and skin and soft tissue infections in the US military health system, 2005-2010.
        JAMA. 2012; 308: 50-59
        • Hadler J.L.
        • Petit S.
        • Mandour M.
        • Cartter M.L.
        Trends in invasive infection with methicillin-resistant Staphylococcus aureus, Connecticut, USA, 2001-2010.
        Emerg Infect Dis. 2012; 18: 917-924
        • Wyllie D.
        • Paul J.
        • Crook D.
        Waves of trouble: MRSA strain dynamics and assessment of the impact of infection control.
        J Antimicrob Chemother. 2011; 66: 2685-2688
        • Pronovost P.
        • Needham D.
        • Berenholtz S.
        • Sinopoli D.
        • Chu H.
        • Cosgrove S.
        • et al.
        An intervention to decrease catheter-related bloodstream infections in the ICU.
        N Engl J Med. 2006; 355: 2725-2732