Background
Colonization of multidrug-resistant microorganisms is a potential source of cross
transmission and subsequent infection. Screening of extended-spectrum β-lactamase-producing
Enterobacteriaceae (ESBL-E) is not yet a routine practice in most hospitals.
Methods
The purpose of this study was to investigate the risk factors of fecal carriage of
ESBL-E in hospitalized patients. A total of 174 samples (from 97 patients) was collected.
Screening test was accomplished using commercial chromogenic medium (ChromID ESBL
agar; bioMérieux, Marcy l'Etoile, France). The presence of ESBLs of grown isolates
was confirmed by Clinical and Laboratory Standards Institute guidelines. Analysis
of the risk factors of ESBL-E carriage was performed by multivariate logistic regression.
Results
Among the risk factors, multivariate analysis demonstrated that prolonged hospitalization
(≥90 days) (odds ratio [OR], 6.76; 95% confidence interval [CI]: 1.17-39.23; P = .033), prolonged intensive care unit stay (≥14 days) (OR, 4.78; 95% CI: 1.70-13.42;
P = .003), and methicillin-resistant Staphylococcus aureus carriage (OR, 3.29; 95% CI: 1.20-9.01; P = .020) were found to be significantly associated with fecal carriers.
Conclusion
This study clarified the characteristics and the risk factors of hospitalized patients
carrying ESBL-E. In addition, the cost-benefit of routine screening in addition to
methicillin-resistant Staphylococcus aureus and vancomycin-resitant Enterococci needs to be assessed.
Key Words
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Article info
Publication history
Published online: August 21, 2013
Footnotes
Supported by Konkuk University in 2013.
Conflicts of interest: None to report.
Identification
Copyright
© 2013 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
