Major article| Volume 41, ISSUE 12, P1241-1243, December 2013

Risk factors of fecal carriage with extended-spectrum β-lactamase-producing Enterobacteriaceae in hospitalized patients

Published:August 21, 2013DOI:


      Colonization of multidrug-resistant microorganisms is a potential source of cross transmission and subsequent infection. Screening of extended-spectrum β-lactamase-producing Enterobacteriaceae (ESBL-E) is not yet a routine practice in most hospitals.


      The purpose of this study was to investigate the risk factors of fecal carriage of ESBL-E in hospitalized patients. A total of 174 samples (from 97 patients) was collected. Screening test was accomplished using commercial chromogenic medium (ChromID ESBL agar; bioMérieux, Marcy l'Etoile, France). The presence of ESBLs of grown isolates was confirmed by Clinical and Laboratory Standards Institute guidelines. Analysis of the risk factors of ESBL-E carriage was performed by multivariate logistic regression.


      Among the risk factors, multivariate analysis demonstrated that prolonged hospitalization (≥90 days) (odds ratio [OR], 6.76; 95% confidence interval [CI]: 1.17-39.23; P = .033), prolonged intensive care unit stay (≥14 days) (OR, 4.78; 95% CI: 1.70-13.42; P = .003), and methicillin-resistant Staphylococcus aureus carriage (OR, 3.29; 95% CI: 1.20-9.01; P = .020) were found to be significantly associated with fecal carriers.


      This study clarified the characteristics and the risk factors of hospitalized patients carrying ESBL-E. In addition, the cost-benefit of routine screening in addition to methicillin-resistant Staphylococcus aureus and vancomycin-resitant Enterococci needs to be assessed.

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