Modifying the risk: Once-a-day bathing “at risk” patients in the intensive care unit with chlorhexidine gluconate

      Chlorhexidine gluconate (CHG) decreases hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) that can cause colonization and infection. A standard approach is the bathing of all patients with CHG to prevent MRSA transmission. To decrease CHG utilization, this study assessed selective daily administration of CHG bathing to intensive care unit patients who had an MRSA-positive result or a central venous catheter. This risk-based approach was associated with a 72% decrease in hospital-acquired MRSA transmission rate.

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        • Denton G.W.
        in: Block S.S. Disinfection, sterilization, and preservation. Lippincott Williams & Wilkins, Philadelphia [PA]2001: 321-336
        • Huang S.
        • Septimus E.
        • Kleinman K.
        • Moody J.
        • Hickok J.
        • Avery T.R.
        • et al.
        Targeted versus universal decolonization to prevent ICU infection.
        N Engl J Med. 2013; 368: 2255-2265
        • Shardell M.
        • Harris A.D.
        • El-Kamary S.S.
        • Furuno J.P.
        • Miller R.R.
        • Perencevich E.N.
        Statistical analysis and application of quasi experiments to antimicrobial resistance intervention studies.
        Clin Infect Dis. 2007; 45: 901-907
        • Climo M.W.
        • Sepkowitz K.A.
        • Zuccotti G.
        • Fraser V.J.
        • Warren D.K.
        • Perl T.M.
        • et al.
        The effect of daily bathing with chlorhexidine on the acquisition of methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, and healthcare-associated bloodstream infections: results of a quasi-experimental multicenter trial.
        Crit Care Med. 2009; 37: 1858-1865
        • Popovich K.J.
        • Hot B.
        • Hayes R.
        • Weinstein R.A.
        • Hayden M.K.
        Effectiveness of routine cleansing with chlorhexidine baths for patients in the medical intensive care unit.
        Infect Control Hosp Epidemiol. 2009; 30: 959-963
        • Evans H.L.
        • Dellit T.H.
        • Chan J.
        • Nathans A.B.
        • Maier R.V.
        • Cushier J.
        Effect of chlorhexidine whole-body bathing on hospital acquired infections among trauma patients.
        Arch Surg. 2010; 145: 240-246
        • Kassakian S.Z.
        • Memel L.A.
        • Jefferson J.A.
        • Parenteau S.L.
        • Machan J.T.
        Impact of chlorhexidine bathing on hospital-acquired infections among general medical patients.
        Infect Control Hosp Epidemiol. 2011; 32: 238-243
        • Climo M.W.
        • Yoke D.S.
        • Warren D.K.
        • Perl T.M.
        • Bolon M.
        • Herwaldt L.A.
        • et al.
        Effect of daily chlorhexidine bathing on hospital-acquired infections.
        N Engl J Med. 2013; 368: 533-542
        • Rupp M.E.
        • Cavalieri R.J.
        • Lyden E.
        • Kucera J.
        • Martin M.
        • Fitzgerald T.
        • et al.
        Effect of hospital-wide chlorhexidine patient bathing on healthcare-associated infections.
        Infect Control Hosp Epidemiol. 2012; 33: 1094-1100