Advertisement

A single genotype of Acinetobacter baumannii expresses multiple antibiotic susceptibility phenotypes

      It is common practice to define a bacterium with unequal antibiotic susceptibility phenotypes as a different genotype. Here, we describe the utility of this practice for Acinetobacter baumannii. We determined antibiotic susceptibility for 19 clinical isolates of A baumannii. Repetitive sequence polymerase chain reaction method was used to determine genotypes. Although all isolates were of the same genotype, 79% were predicted to be different based on susceptibility patterns. The antibiotic susceptibility phenotype does not accurately predict the genotype of A baumannii.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Infection Control
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Sabat A.J.
        • Budimir A.
        • Nashev D.
        • Sa-Leao R.
        • van Dijl J.
        • Laurent F.
        • et al.
        Overview of molecular typing methods for outbreak detection and epidemiological surveillance.
        Euro Surveill. 2013; 18: 20380
        • Aldea-Mansilla C.
        • Garcia de Viedma D.
        • Cercenado E.
        • Martin-Rabadan P.
        • Marin M.
        • Bouza E.
        Comparison of phenotypic with genotypic procedures for confirmation of coagulase-negative Staphylococcus catheter-related bloodstream infections.
        J Clin Microbiol. 2006; 44: 3529-3532
        • Garcia de Viedma D.
        • Martin Rabadan P.
        • Diaz M.
        • Cercenado E.
        • Bouza E.
        Heterogeneous antimicrobial resistance patterns in polyclonal populations of coagulase-negative staphylococci isolated from catheters.
        J Clin Microbiol. 2000; 38: 1359-1363
        • Jung S.
        • Yu J.K.
        • Shin S.H.
        • Park K.G.
        • Jekarl D.W.
        • Han K.
        • et al.
        False susceptibility to amikacin by VITEK 2 in Acinetobacter baumannii harboring armA.
        Ann Clin Lab Sci. 2010; 40: 167-171
        • Kulah C.
        • Aktas E.
        • Comert F.
        • Ozlu N.
        • Akyar I.
        • Ankarali H.
        Detecting imipenem resistance in Acinetobacter baumannii by automated systems (BD Phoenix, Microscan WalkAway, Vitek 2); high error rates with Microscan WalkAway.
        BMC Infect Dis. 2009; 9: 30