Major article| Volume 42, ISSUE 11, P1178-1181, November 2014

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Long-term efficacy of a self-disinfecting coating in an intensive care unit


      Cleaning and disinfecting fomites can effectively remove/kill pathogens on surfaces, but studies have shown that more than one-half the time, surfaces are not adequately cleaned or are recontaminated within minutes. This study evaluated a product designed to create a long-lasting surface coating that provides continuous disinfecting action.


      This study was performed in an intensive care unit (ICU) in a major hospital. Various sites within the ICU were cultured before treatment and then at 1, 2, 4, 8, and 15 weeks after application of an antimicrobial coating. Samples were cultured for total bacteria, as well as Clostridium difficile, methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococcus, and carbapenemase-resistant Enterobacteriaceae.


      The average bacterial count on all treated surfaces was reduced by >99% (2 logs) for at least 8 weeks after treatment. Overall, average levels of bacteria never returned to those observed before treatment even after 15 weeks. Antibiotic-resistant bacteria were found on 25% of the sites tested before treatment, but were isolated at only 1 site during the 15 weeks after treatment.


      The product assessed in this study was found to have persisted over 15 weeks in reducing the total number of bacteria and antibiotic resistant bacteria on surfaces within an ICU.

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        • Weber D.J.
        • Anderson D.
        • Rutala W.A.
        The role of the surface environment in healthcare-associated infections.
        Curr Opin Infect Dis. 2013; 26: 338-344
        • Carling P.C.
        • Bartley J.M.
        Evaluating hygienic cleaning in health care settings: what you do not know can harm your patients.
        Am J Infect Control. 2010; 38: S41-50
        • Attaway 3rd, H.H.
        • Fairey S.
        • Steed L.L.
        • Salgado C.D.
        • Michels H.T.
        • Schmidt M.G.
        Intrinsic bacterial burden associated with intensive care unit hospital beds: effects of disinfection on population recovery and migration of potential infection risk.
        Am J Infect Control. 2012; 40: 907-912
        • Engelbrecht K.
        • Ambrose D.
        • Sifuentes L.
        • Gerba C.P.
        • Weart I.
        • Koenig D.
        Decreased activity of commercially available disinfectants containing quaternary ammonium compounds when exposed to cotton towels.
        Am J Infect Control. 2013; 41: 908-911
        • Weber D.J.
        • Rutala W.A.
        Self-disinfecting surfaces: review of current methologies and future prospects.
        Am J Infect Control. 2013; 41: S31-S35
        • Salgado C.D.
        • Sepkowitz K.A.
        • John J.F.
        • Cantey J.R.
        • Attaway H.H.
        • Freeman K.D.
        • et al.
        Copper surfaces reduce the rate of health-acquired infections in the intensive care unit.
        Infect Control Hospital Epidemiol. 2013; 34: 479-486
        • Karpanen T.J.
        • Casey A.L.
        • Lambert P.A.
        • Cookson B.D.
        • nightingale P.
        • Miruszenko L.
        • et al.
        The antimicrobial efficacy of copper alloy furnishing in the clinical environment: a crossover study.
        Infect Control Hospital Epidemiol. 2012; 33: 3-9
        • Schmidt M.G.
        • Attaway H.H.
        • Fairey S.E.
        • Steed L.L.
        • Michels H.T.
        • Salgado C.D.
        Copper continuously limits the concentration of bacteria resident on bed rails within the intensive care unit.
        Infect Control Hosp Epidemiol. 2013; 34: 530-533
        • van der Linde K.
        • Lim B.T.
        • Rondeel A.M.
        • Lea P.M.T.
        • de Jong A.M.T.
        Improved bacteriological surveillance of hemodialysis fluids: a comparison between trypic soy agar and Reasoner’s 2A media.
        Nephrol Dial Transplant. 1999; 14: 2433-2437
        • Reasoner D.J.
        Heterotrophic plate count methodology in the United States.
        Intl J Food Microbiol. 2004; 92: 307-315
        • Kabacoff R.I.
        R in action: data analysis and graphics with R.
        Manning Publications, Shelter Island, [NY]2011
        • Zumel N.
        • Mount J.
        Practical data science with R.
        Manning Publications, Shelter Island, [NY]2013
        • Sexton J.D.
        • Tanner B.D.
        • Maxwell S.L.
        • Gerba C.P.
        Reduction in the microbial load on high-touch surfaces in hospital rooms by treatment with a portable saturated stream vapor disinfection system.
        Am J Infect Control. 2011; 79: 655-662
        • Songer J.S.
        • Trinh H.T.
        • Kilgore G.E.
        • Tompson A.D.
        • McDonald
        • Limbago B.M.
        Clostridium difficile in retail meat products, USA, 2007.
        Emerg Infect Dis. 2009; 15: 819-821
      1. Centers for Disease Control and Prevention. Laboratory detection of: oxacillin/methicillian-resistant Staphylococcus aureus. Available from: Accessed January 10, 2013.

      2. Centers for Disease Control and Prevention. Modified Hodge test for carbapenemase detection in Enterobacteriaceae. Available from: Assessed January 10, 2013.

      3. Centers for Disease Control and Prevention. Vancomycin-resistant enterococci (VRE) and clinical laboratory. Available from: Accessed January 10, 2013.

        • Boyce J.M.
        • Havill N.L.
        • Guercia K.A.
        • Schweon S.J.
        • Moore B.A.
        Evaluation of two organosilane products for sustained antimicrobial activity on high-touch surfaces in patient rooms.
        Am J Infect Control. 2014; 42: 326-328
        • McDonell G.E.
        Antisepsis, disinfection, and sterilization.
        ASM Press, Washington, DC2007