From 2009-2012, a total of 281 episodes of central line–associated candidemia were
identified, and the overall incidence was 2.05 episodes per 1,000 hospital admissions.
More than half of the patients were classified as older adults, with an age ≥65 years.
Cancer was the most common underlying disease (n = 231, 82.2%). Twenty patients had
polycandidal candidemia, and 94 had concomitant bacteremia. The overall in-hospital
mortality rate was 50.9%, and a multivariable analysis showed that this rate was only
significantly associated with a Charlson comorbidity index score >5, jaundice, no
antifungal agent use, and use of mechanical ventilators.
Key Words
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References
- Epidemiology of invasive fungal infections in the intensive care unit: results of multicenter Italian survey (AURORA Project).Infection. 2013; 41: 645-653
- The changing epidemiology of healthcare-associated candidemia over three decades.Diagn Microbiol Infect Dis. 2012; 73: 45-48
- Invasive candidiasis: an overview from Taiwan.J Formos Med Assoc. 2009; 108: 443-451
- Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.Clin Infect Dis. 2004; 39: 309-317
- Candida bloodstream infections in intensive care unit: analysis of the extended prevalence of infection in intensive care unit study.Crit Care Med. 2011; 39: 665-670
- Determinants of mortality in non-neutropenic ICU patients with candidaemia.Crit Care. 2009; 13: R115
- Assessment of candidemia-attributable mortality in critically ill patients using propensity score matching analysis.Crit Care. 2012; 16: R105
- Candidaemia in adult cancer patients: risk for fluconazole-resistant isolates and death.J Antimicrob Chemother. 2010; 65: 1042-1051
- Stable susceptibility of Candida blood isolates to fluconazole despite increasing use during the past 10 years.J Antimicrob Chemother. 2003; 52: 71-77
- TSARY Hospitals. Susceptibilities to amphotericin B and fluconazole of Candida species in Taiwan Surveillance of Antimicrobial Resistance of Yeasts 2006.Diagn Microbiol Infect Dis. 2008; 61: 175-180
Article info
Publication history
Published online: September 17, 2014
Footnotes
Conflicts of interest: None to report.
Funding: None.
Author contributions: Draft preparation: Tang. Data analysis: Liu and Lin. Data acquisition: Lai. Critical review and approval of final version: Lai.
Identification
Copyright
© 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.