Background
The spread of multidrug-resistant tuberculosis (MDR-TB) is a major public health problem
worldwide. Although drug resistance is common in some countries and rare in others,
the extent of this condition is not precisely known in Iran.
Methods
We searched several databases including PubMed, Web of Science, Scopus, Iran Medex,
and Scientific Information Database to identify studies addressing drug-resistant
tuberculosis in Iran. A total of 19 reports published from different regions of Iran
from March 1999-May 2013 were included in this study.
Results
The meta-analyses revealed that 23% (95% confidence interval [CI], 21.8-24.2) of new
cases and 65.6% (95% CI, 62.5-68.5) of previously treated cases were resistant to
at least 1 drug. Furthermore, MDR-TB was found in 5.1% (95% CI, 4.4-5.8) of new cases,
whereas it was found in 33.7% (95% CI, 30.8-36.7) of retreatment cases. The highest
rate of resistance in new and previously treated cases was seen against streptomycin
(19%) and isoniazid (47%), respectively.
Conclusion
The results of the present study underscore the need for further enforcement of TB
control strategies. Drug susceptibility testing, establishing advanced diagnostic
facilities, and continuous monitoring of drug resistance are recommended for prevention
and control of MDR-TB.
Key Words
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Article info
Publication history
Published online: September 18, 2014
Footnotes
Conflict of interest: None to report.
Identification
Copyright
© 2014 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
