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Assessment of an innovative antimicrobial surface disinfectant in the operating room environment using adenosine triphosphate bioluminescence assay

      Terminal cleaning in the operating room is a critical step in preventing the transmission of health care–associated pathogens. The persistent disinfectant activity of a novel isopropyl alcohol/organofunctional silane solution (ISO) was evaluated in 4 operating rooms after terminal cleaning. Adenosine triphosphate bioluminescence documented a significant difference (P < .048) in surface bioburden on IOS-treated surfaces versus controls. RODAC plate cultures revealed a significant (P < .001) reduction in microbial contamination on IOS-treated surfaces compared with controls. Further studies are warranted to validate the persistent disinfectant activity of ISO within selective health care settings.

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      References

        • Otter J.A.
        • Vesli S.
        • French G.L.
        The role played by contaminated surfaces in the transmission of nosocomial pathogens.
        Infect Control Hosp Epidemiol. 2011; 32: 687-699
        • Hayden M.K.
        • Bonten M.J.
        • Blom D.W.
        • Lyle E.A.
        • van de Vijver D.A.
        • Weinstein R.A.
        Reduction in acquisition of vancomycin-resistant enterococcus after enforcement of routine environmental cleaning measures.
        Clin Infect Dis. 2006; 42: 1552-1560
        • Datta R.
        • Platt R.
        • Yokoe D.S.
        • Huang S.S.
        Environmental cleaning intervention and risk of acquiring multidrug-resistant organisms from prior room occupants.
        Arch Intern Med. 2011; 171: 491-494
        • Passaretti C.L.
        • Otter J.A.
        • Reich N.G.
        • Myers J.
        • Shepard J.
        • Ross T.
        • et al.
        An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms.
        Clin Infect Dis. 2013; 56: 27-35
        • Dell L.A.
        Aspects of microbiological monitoring for nonsterile and sterile manufacturing environments.
        Pharm Technol. 1979; 3: 47-51
      1. Guh A, Carling P, Environmental Evaluation Workgroup. Options for evaluating environmental cleaning. Available from: http://www.cdc.gov/HAI/pdfs/toolkits/Environ-Cleaning-Eval-Toolkit12-2-2010.pdf. Accessed October 6, 2014.

        • Boyce J.M.
        • Havill N.L.
        • Dumigan D.G.
        • Golebiewski M.
        • Balogun O.
        • Rszvani R.
        Monitoring the effectiveness of hospital cleaning practices by use of an adenosine triphosphate bioluminescence assay.
        Infect Control Hosp Epidemiol. 2009; 30: 678-684
        • Mulvey D.
        • Redding P.
        • Robertson C.
        • Woodall C.
        • Kingsmore P.
        • Bedwell D.
        • et al.
        Finding a benchmark for monitoring hospital cleaniness.
        J Hosp Infect. 2011; 77: 25-30
        • Branch-Elliman W.
        • Robillard E.
        • McCrthy G.
        • Gupta K.
        Direct feedback with ATP luminometer as a process improvement tool for terminal cleaning of patient rooms.
        Am J Infect Control. 2014; 42: 195-197
        • Smith P.W.
        • Beam E.
        • Sayles H.
        • Rupp M.E.
        • Cavaliere R.J.
        • Gibbs S.
        • et al.
        Impact of adenosine triphosphate detection and feedback on hospital room cleaning.
        Infect Control Hosp Epidemiol. 2014; 35: 564-569
        • Boyce J.M.
        • Havill N.L.
        • Guerica K.W.
        • Schweon S.J.
        • Moore B.A.
        Evaluation of two organosilane products for sustained antimicrobial activity on high touch surfaces in patient rooms.
        Am J Infect Control. 2014; 42: 326-328