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Efficacy of a novel skin antiseptic against carbapenem-resistant Enterobacteriaceae

  • Timothy L. Wiemken
    Correspondence
    Address correspondence to Timothy L. Wiemken, PhD, MPH, CIC, Clinical and Translational Research Support Unit, Division of Infectious Diseases, Department of Medicine, Louisville, University of Louisville School of Medicine, Louisville, KY 40205.
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Robert R. Kelley
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Ruth M. Carrico
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Laura E. Binford
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Brian E. Guinn
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • William A. Mattingly
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Paula Peyrani
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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  • Julio A. Ramirez
    Affiliations
    University of Louisville School of Medicine, Department of Medicine, Division of Infectious Diseases, Clinical and Translational Research Support Unit, Healthcare Epidemiology Program, Louisville, KY
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Published:February 05, 2015DOI:https://doi.org/10.1016/j.ajic.2014.12.007

      Highlights

      • Carbapenem-resistant Enterobacteriaceae plague health care settings.
      • Activity of a silver-based skin antiseptic against carbapenem-resistant Enterobacteriaceae was evaluated.
      • A human skin analog was used to test the product activity.
      • The silver-based skin antiseptic greatly reduced both carbapenem-resistant Enterobacteriaceae tested.
      • This product may be useful for carbapenem-resistant Enterobacteriaceae control through patient bathing.
      Infections caused by carbapenem-resistant Enterobacteriaceae (CRE) are increasing on a global scale. Because of the need for CRE transmission prevention and control, we sought to evaluate the efficacy of a silver-based skin antiseptic against these organisms. Using a human skin analog, a third party laboratory conducted efficacy testing. The results suggest that this product provides antimicrobial activity against CRE on human skin. Because of the unique properties, this antiseptic may be useful for daily bathing of hospitalized patients to assist in the control of CRE.

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