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Dissemination of antibiotic resistance in methicillin-resistant Staphylococcus aureus and vancomycin-resistant S aureus strains isolated from hospital effluents

Published:September 29, 2015DOI:https://doi.org/10.1016/j.ajic.2015.08.015

      Highlights

      • Both methicillin-resistant Staphylococcus aureus and vancomycin-resistant S aureus strains were identified from hospital effluents.
      • Approximately 15% isolates were vancomycin resistant and all were methicillin resistant.
      • The vancomycin-resistant Staphylococcus aureus strains developed a VanR/VanS-regulated 2-component system of VanA-type resistance in their genome.
      • Vancomycin-resistant Staphylococcus aureus strains may have a possibility to develop resistance against aminoglycosides antibiotics in the near future.
      • Proper treatment of hospital-associated discharge is vital to stop the cross talk between pathogenic and nonpathogenic bacteria.
      Vancomycin-resistant Staphylococcus aureus (VRSA) and methicillin-resistant S aureus (MRSA) strains were examined in hospital effluents. Most S aureus strains are resistant to methicillin (MRSA), followed by tetracycline. Approximately 15% of MRSA strains are also resistant to vancomycin (VRSA). All VRSA strains developed a VanR/VanS-regulated 2-component system of VanA-type resistance in their genome. Results indicate that there is a possibility of developing resistance to aminoglycosides by VRSA strains in the near future.

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