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Epidemiology of Clostridium difficile infection in hospitalized oncology patients

      Highlights

      • We identified risk factors for Clostridium difficile infection in oncology patients.
      • Risk factors evaluated included demographic variables, cancer treatment, and antibiotic use.
      • Age, prior blood transfusion, and receipt of specific antibiotic classes were associated with Clostridium difficile infection.
      • Prior history of Clostridium difficile infection (CDI) was a highly significant risk factor for CDI.
      • Hospitalized oncology patients may be particularly high risk for Clostridium difficile infection.
      The epidemiology of Clostridium difficile infection (CDI) among oncology inpatients is poorly understood. In multivariate analysis we identified age, history of CDI, and prior receipt of cephalosporins, β-lactam/β-lactamase inhibitors, metronidazole, and blood transfusion as risk factors associated with CDI. Reducing broad-spectrum antibiotic use, particularly among older patients and those with a CDI history and recent blood transfusions, may decrease CDI risk in this population.

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