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Epidemiologic characteristics, clinical manifestations, and risk factors of 139 patients with Ebola virus disease in western Sierra Leone

      Highlights

      • The 2014 West Africa Ebola virus outbreak is the largest Ebola virus disease (EVD) epidemic on record, and Sierra Leone is one of the severe outbreak sites.
      • This study fully described epidemiological characteristics, clinical manifestations and clinical outcomes of 139 laboratory-confirmed EVD patients who admitted to the JUI Holding and Treatment Centre in western Sierra Leone between 15 November, 2014 and 18 January, 2015.
      • The median age of investigated patients was 29 years and 55.4% were female. Of them, 76 patients (54.7%) died, and 63 patients (45.3%) were cured.
      • Our data showed that mortality of EVD was associated with an older age, fever and probably hiccups.

      Objective

      We aimed to fully describe epidemiologic characteristics, clinical manifestations, and clinical outcomes of Ebola virus disease (EVD), as well as detect independent factors significantly associated with mortality of the disease.

      Methods

      One hundred thirty-nine confirmed EVD patients enrolled at the JUI Holding and Treatment Centre in western Sierra Leone between November 15, 2014, and January 18, 2015, and demographic and clinical data were retrospectively collected and analyzed.

      Results

      The median age of investigated patients was 29 years and 55.4% were women. Of them, 76 patients (54.7%) died and 63 patients (45.3%) were cured. Case fatality rate among male patients was higher than in female patients (69.4% vs 42.9%). Fatigue (82.0%), anorexia (70.5%), abdominal pain (59.7%), diarrhea (58.3%), vomiting (56.1%), fever (55.4%), and muscle pain (54.0%) were the most common symptoms. In addition, 55.4% of investigated patients reported fever. Bleeding was seen in 10.8% of patients.

      Conclusions

      Our data show that mortality of EVD is associated with an older age, fever, and probably hiccups.

      Key Words

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