- •Time spent on training may reflect attitude to follow adopted protocols.
- •Training is the most important factor to support new practices.
- •It takes some time before hospital staff could apply protocols in a correct way.
- •Length of hospitalization is a risk factor for development of Clostridium difficile–associated disease.
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Conflicts of Interest: None to report.
Author Contributions: S.C. and G.F. contributed to the concept and rationale for the study. G.D. and S.S. wrote the manuscript. G.D., S.S., M.M., and S.F. were involved in clinical and epidemiologic data collection. A.M. and F.S. performed microbiologic analysis. D.C. contributed to data analysis. M.L. and M.D.C. contributed to interpretation of the results. All authors participated in drafting and approval of the final manuscript and take responsibility for content and interpretation of this article.
Additional Information: No ethical approval is required for this study according to national law number 196 of the year 2003 and the regional law of the Lombardia Region number 3 of the year 2012.