Non-Compliance with Testing Guidelines May Contribute to an Artificially High Rate of Hospital-Onset Clostridium difficile

      BACKGROUND: Clostridium difficile (C. difficile) is a major cause of healthcare-associated infections. However, recent studies suggest that rates of C. difficile infections may be exaggerated due to the high sensitivity of molecular testing that do not differentiate colonization from infection. In addition, non-compliance with published testing guidelines may also contribute to these artificially high rates. The goal of this study is to assess the impact of non-compliance with these guidelines on the rate of hospital-onset (HO) C. difficile.
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