What is the Association between Repeat Gram Negative Healthcare-Associated Infections and Antibiotic Susceptibility? A Systematic Review

      BACKGROUND: Nearly 700,000 patients are infected with healthcare-associated infections (HAIs) in the United States each year. Repeat HAIs among frequently hospitalized patients may be contributing to the high rates of antibiotic resistance seen in gram negative bacteria (GNB) in hospital settings. The effect of prior antibiotic use and antibiotic stewardship on antibiotic resistance has been well documented. However, less is known about the role of previous GNB HAIs on antibiotic susceptibility in subsequent HAIs with the same organism in an individual patient. This systematic review examines the state of the literature assessing the association between repeat GNB HAIs and changes in antibiotic susceptibility patterns across multiple infections.
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