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Booster influenza vaccination confers additional immune responses in an elderly, rural community-dwelling population

Published:November 14, 2017DOI:https://doi.org/10.1016/j.ajic.2017.09.034

      Highlights

      • Two doses of influenza vaccine were administered to the elderly aged 61-102 years.
      • Antibody responses 22 weeks after the vaccination were measured.
      • Seroprotection rates (PRs) against the A(H3N2) and B strains were maintained.
      • The PR against the A(H1N1)pdm09 strain in people aged 61-75 years did not decrease.
      This study aimed to examine the effects of a booster vaccination in elderly people using 2 doses of trivalent inactivated influenza vaccine during the 2012-2013 influenza epidemic. Seroprotection rates against the A(H1N1)pdm09 strain in younger elderly people (aged 61-75 years) and the A(H3N2) and B strains in both younger elderly people (aged 61-75 years) as well as very elderly people (aged 76-102 years) did not decrease at 22 weeks after vaccination. This approach confers long-lasting antibody responses and may be useful in clinical practice.

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