- •Transmission, effects on pregnancy, and travel were the top 3 Zika themes on Twitter.
- •News media, public health institutions, and grassroots users exert the most influence.
- •News media play an important role during EIDOS by spreading information via Twitter.
- •Grassroots users are very visible; they amplify social concerns and conspiracy theories.
- •Social media analytics can strengthen public health agencies' efforts during EIDOs.
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Conflicts of interest: None to report.