Highlights
- •Antimicrobial stewardship can be impacted by antibiotic duration orders.
- •Wording of antibiotic duration orders can impact the number of doses administered.
- •Neonates with doses beyond the anticipated duration was reduced from 50%-7.2%.
The wording of the antibiotic duration orders for neonatal sepsis was changed as an
antimicrobial stewardship initiative to reduce the administration of unnecessary antibiotic
doses. The change in wording allowed the patient to stop receiving antibiotics after
they received 48 hours of therapy if the health care team had not received notification
of a positive culture. This initiative led to a decrease in the number of neonates
that received extra unnecessary doses from 50% to 7.2%.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Infection ControlAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Early-onset neonatal sepsis.Clin Microbiol Rev. 2014; 27: 21-47
- Reducing antibiotic utilization rate in preterm infants: a quality improvement initiative.J Perinatol. 2018; 38: 421-429
- Challenges and opportunities for antibiotic stewardship among preterm infants.Arch Dis Child Fetal Neonatal Ed. 2018; 0: F1-F6
- Reducing unnecessary antibiotic use in the neonatal intensive care unit (SCOUT): a prospective interrupted time-series study.Lancet Infect Dis. 2016; 16: 1178-1184
- Duration of initial empirical antibiotic therapy and outcomes in very low birth weight infants.Pediatrics. 2019; 143e20182286
- Association of antibiotic utilization and neurodevelopmental outcomes among extremely low gestational age neonates without proven sepsis or necrotizing enterocolitis.Am J Perinatol. 2018; 35: 972-978
- Antibiotic therapy in neonates and impact on gut microbiota and antibiotic resistance development: a systematic review.J Antimicrob Chemother. 2018; 73: 569-580
- Development, evaluation and validation of a screening tool for late onset bacteremia in neonates – a pilot study.BMC Pediatr. 2019; 19: 253
- Antibiotics in the environment.Ups J Med Sci. 2014; 119: 108-112
Article info
Publication history
Published online: June 17, 2020
Footnotes
Conflicts of interest: None to report.
Identification
Copyright
© 2020 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.