Objectives
Methods
Results
Conclusions
Key Words
Introduction
Spanish Ministry of Health. New coronavirus disease. https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Informacion_inicial_alerta.pdf. Accessed April 26, 2020.
Reuters. Wuhan lockdown ‘unprecedented’, shows commitment to contain virus: WHO representative in China. https://www.reuters.com/article/us-china-health-who-idUSKBN1ZM1G9. Accessed April 26, 2020.
Spanish Ministry of Health. New coronavirus disease. https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Informacion_inicial_alerta.pdf. Accessed April 26, 2020.
World Health Organization (WHO). WHO Director-General's opening remarks at the media briefing on COVID-19. https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19—11-march-2020. Accessed April 26, 2020.
World Health Organization (WHO). Middle East respiratory syndrome coronavirus (MERS-CoV). Available at: https://www.who.int/news-room/q-a-detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov). Accessed April 26, 2020.
World Health Organization (WHO). Middle East respiratory syndrome coronavirus (MERS-CoV). Available at: https://www.who.int/news-room/q-a-detail/middle-east-respiratory-syndrome-coronavirus-(mers-cov). Accessed April 26, 2020.
European Centre for Disease Prevention and Control (ECDC). Situation update worldwide, as of 26 April 2020. Available at: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases. Accessed April 26, 2020.
World Health Organization (WHO). Summary of SARS and air travel. Available at:https://www.who.int/csr/sars/travel/airtravel/en/. Accessed April 26, 2020.
Spanish Ministry of Health. Update 31: Coronavirus disease (COVID-19). Available at: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_31_COVID-19.pdf. Accessed April 26, 2020.
Spanish State Official Newsletter (BOE). Royal Decree 463/2020, of March 14, declaring the state of alarm for the management of the health crisis situation caused by COVID-19. Available at: https://www.boe.es/boe/dias/2020/03/14/pdfs/BOE-A-2020-3692.pdf. Accessed April 26, 2020.
European Centre for Disease Prevention and Control (ECDC). Situation update worldwide, as of 26 April 2020. Available at: https://www.ecdc.europa.eu/en/geographical-distribution-2019-ncov-cases. Accessed April 26, 2020.

Spanish State Official Newsletter (BOE). Royal Decree 2210/1995, of December 28, creating the National Epidemiological Surveillance Network. Available at: https://www.boe.es/buscar/doc.php?id=BOE-A-1996-1502. Accessed April 27, 2020.
Main objective
Material and methods

Results
Patients characteristics


SARS-COV-2 confirmed cases | |||
---|---|---|---|
Results | Patients with positive PCR (n = 1,243; 68%) | Clinical diagnosis (n = 585; 32%) | P value |
Characteristics of patients | |||
Age | |||
average in years, (SD) | 63.4 (18.6) | 66.6 (18.7) | <.01 |
Age group in years (%) | |||
< 2 | 2 (0.2%) | 0 (0%) | .04 |
2-4 | 0 (0%) | 0 (0%) | |
5-14 | 0 (0%) | 0 (0%) | |
15-29 | 56 (4.5%) | 14 (2.4%) | |
30-39 | 80 (6.4%) | 32 (5.5%) | |
40-49 | 178 (14.3%) | 84 (14.4%) | |
50-59 | 194 (15.6%) | 78 (13.3%) | |
60-69 | 206 (16.6%) | 92 (15.7%) | |
70-79 | 247 (19.9%) | 102 (17.4%) | |
≥ 80 | 280 (22.5%) | 183 (31.3%) | |
Gender | |||
Male (%) | 653 (52.5%) | 291 (49.7%) | .27 |
Female (%) | 590 (47.5%) | 294 (50.3%) | |
Known health care professional | |||
Yes (%) | 31 (2.5%) | 2 (0.3%) | .01 |
Characteristics of hospital admission | |||
Emergency Department | |||
Patients currently discharged (%) | 1,242 (99.6%) | 583 (99.7%) | .20 |
Average stay in days at the Emergency Department, (SD) | 1.2 (0.9) | 1.2 (0.8) | .74 |
Number of times patients were attended at Infanta Sofía University Hospital (%) | |||
1 | 896 (72.1%) | 402 (62.7%) | .38 |
2 | 241 (19.4%) | 114 (19.5%) | |
3 | 73 (5.9%) | 47 (8%) | |
4 | 21 (1.7%) | 15 (2.6%) | |
5 | 6 (0.5%) | 4 (0.7%) | |
6 | 6 (0.5%) | 3 (0.5%) | |
Number of patients who have been to the hospital more than once (%) | 347 (27.9%) | 183 (31.3%) | .14 |
Hospitalisation | |||
Patients who were hospitalised (%) | 804 (64.7%) | 335 (57.3%) | <.01 |
Patients currently discharged (%) | 801 (98.5%) | 358 (98.4%) | .82 |
Patients currently hospitalised as of June 29, 2020 | 12 (15.5%) | 6 (22.0%) | .82 |
Average stay in days of hospitalisation, (SD) | 11.1 (12) | 8.1 (8.4) | <.01 |
Readmission (%) | 61 (4.9%) | 51 (8.7%) | |
Noninvasive mechanical ventilation (%) | 76 (10.0%) | 14 (5.9%) | .06 |
Intensive care unit | |||
Patients who were admitted to the ICU (%) | 83 (6.7%) | 20 (3.4%) | .00 |
Patients currently discharged (%) | 79 (95.2%) | 20 (100%) | .32 |
Patients currently hospitalised as of June 29, 2020 | 4 (4.8%) | 0 (0%) | .32 |
Average stay in days in ICU, (SD) | 18.8 (8.0) | 7.5 (3.0) | .02 |
Mortality | |||
Number of deaths (%) | 195 (15.7%) | 74 (12.7%) | .08 |
Emergency department | 19 (9.7%) | 17 (22.9%) | <.01 |
Hospitalisation | 142 (72.8%) | 55 (74.3%) | |
ICU | 34 (17.4%) | 2 (2.7%) |

Epidemiological curve

Discussion
Spanish Ministry of Health. Update 49: Coronavirus disease (COVID-19). Available at: https://www.mscbs.gob.es/profesionales/saludPublica/ccayes/alertasActual/nCov-China/documentos/Actualizacion_49_COVID-19.pdf. Accessed April 27, 2020.
Limitations
Madrid Health Board. The Region reorganises urgent Paediatric Care to avoid possible infections by coronavirus to patients and parents/legal guardians. Available at: https://www.comunidad.madrid/sites/default/files/doc/sanidad/comu/200321_comunicado_sanidad_coronavirus_centros_urgencias_atencion_pediatrica_0.pdf. Accessed April 28, 2020.
Conclusions
Madrid Health Board. The Region reorganises urgent Paediatric Care to avoid possible infections by coronavirus to patients and parents/legal guardians. Available at: https://www.comunidad.madrid/sites/default/files/doc/sanidad/comu/200321_comunicado_sanidad_coronavirus_centros_urgencias_atencion_pediatrica_0.pdf. Accessed April 28, 2020.
Acknowledgments
Appendix. SUPPLEMENTARY MATERIALS
References
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Article info
Publication history
Footnotes
†COVID Epidemiological Surveillance and Control Study Group: Ana Isabel Bajo Martínez, Vanesa Barroso Gómez, Cristina Bayón García, Fernando Cava Valenciano, Rosa María Ceballos Rodríguez, Raquel Coca Serrano, Manuel Freire Magariños, Andrea González Prieto, Patricia González-Ruano Pérez*, Francisco Javier Guerra Aguirre, Luz María Jiménez Losa, María Luisa Loayza Escalante, Paola Maldonado Cid, María Dolores Martín Rodrigo, María de los Ángeles Martos Cano, Raúl Moreno Zabaleta*, Manuel Moriche Carretero*, Laura Parro Herrero, Antonio Revuelta Alonso, Fernando Ruisánchez Inés, María Pilar Ruiz Seco*, Elena Saez Alonso, Jorge Sanjurjo Portús*, Gonzalo Serralta San Martín*, Belén Ubach Badia, Ricardo Valverde Garrido (Infanta Sofía University Hospital, San Sebastián de los Reyes (Madrid), Spain; *Universidad Europea, Madrid, Spain).
†Conflicts of interest: None to report.
†Author contributions: All authors contributed to the study conception and design. Material preparation and analysis were performed by L.D.I., C.G. and C.G.F. Data collection was performed by the COVID Epidemiological Surveillance and Control Study Group. The first draft of the manuscript was written by C.G. and L.D.I. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
†Availability of data and material: Data was obtained from hospital records as described above. Institutional Investigation Review Board approval was obtained.
†Code availability: Excel (Version 2010, Microsoft Corporation, Richmond, WA, USA). Stata (Version 15).