- •222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 0.94 log10 in 10 seconds.
- •222-nm UVC light (0.1 mW/cm2) reduced viable SARS-CoV-2 by 2.51 log10 in 30 seconds.
- •222-nm UVC light did not reduce SARS-CoV-2 RNA copy number after 5-minute irradiation.
- •TSID50 and not RT-qPCR should be used to monitor far-UVC disinfection of surfaces.
- Simmons S
- Carrion R
- Alfson K
- et al.
Cells and virus
222-nm UVC disinfection
Quantitative reverse transcription PCR (RT-qPCR)
|UVC irradiation time|
|Control||10 seconds||30 seconds||60 seconds||300 seconds|
|Mean viable SARS-CoV-2 (TICD50/mL) (SD)||2.05 ± 1.21 × 104||2.34 ± 0.86 × 103||6.32 ± 0.0 × 101||6.32 ± 0.0 × 101||6.32 ± 0.0 × 101|
|Mean SARS-CoV-2 RNA|
|2.12 ± 0.27 × 107||5.75 ± 0.82 × 107||3.41 ± 1.08 × 107||2.95 ± 0.41 × 107||3.03 ± 1.73 × 107|
- Simmons S
- Carrion R
- Alfson K
- et al.
- Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia.N Engl J Med. 2020; 382: 1199-1207
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China.Lancet. 2020; 395: 497-506
- Aerosol and surface stability of SARS-CoV-2 as compared with SARS-CoV-1.N Engl J Med. 2020; 382: 1564-1567
- Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents.J Hosp Infect. 2020; 104: 246-251
- Environmental contamination by SARS-CoV-2 in a designated hospital for coronavirus disease 2019.Am J Infect Control. 2020; 48: 910-914
- Air, surface environmental, and personal protective equipment contamination by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from a symptomatic patient.JAMA. 2020; 323: 1610-1612
- Environmental contamination of SARS-CoV-2 in healthcare premises.J Infect. 2020; 81: e1-e5
- No-touch disinfection methods to decrease multidrug-resistant organism infections: a systematic review and meta-analysis.Infect Control Hosp Epidemiol. 2018; 39: 20-31
- Germicidal efficacy and mammalian skin safety of 222-nm UV light.Radiat Res. 2017; 187: 483-491
- Disinfection and healing effects of 222-nm UVC light on methicillin-resistant Staphylococcus aureus infection in mouse wounds.J Photochem Photobiol B. 2018; 178: 10-18
- Chronic irradiation with 222-nm UVC light induces neither DNA damage nor epidermal lesions in mouse skin, even at high doses.PLoS One. 2018; 13e0201259
- Long-term effects of 222-nm ultraviolet radiation C sterilizing lamps on mice susceptible to ultraviolet radiation.Photochem Photobiol. 2020; 96: 853-862
- Ultraviolet C light with wavelength of 222 nm inactivates a wide spectrum of microbial pathogens.J Hosp Infect. 2020; 105: 459-467
- Far-UVC light: a new tool to control the spread of airborne-mediated microbial diseases.Sci Rep. 2018; 8: 2752
- Far-UVC light (222 nm) efficiently and safely inactivates airborne human coronaviruses.Sci Rep. 2020; 10: 10285
- Deactivation of SARS-CoV-2 with pulsed xenon ultraviolet: Implications for environmental COVID-19 control [e-pub ahead of print].Infect Control Hosp Epidemiol. 2020; (Accessed September 10, 2020)https://doi.org/10.1017/ice.2020.399
- Susceptibility of SARS-CoV-2 to UV irradiation.Am J Infect Control. 2020; 48: 1273-1275
- Enhanced isolation of SARS-CoV-2 by TMPRSS2-expressing cells.Proc Natl Acad Sci USA. 2020; 117: 7001-7003
- Inactivation of pathogenic viruses by plant-derived tannins: strong effects of extracts from persimmon (Diospyros kaki) on a broad range of viruses.PLoS One. 2013; 8: e55343
- Estimating the asymptomatic proportion of coronavirus disease 2019 (COVID-19) cases on board the Diamond Princess cruise ship, Yokohama, Japan, 2020.Euro Surveill. 2020; 252000180
Funding: This work was supported by the Japan Agency for Medical Research and Development (AMED) under grant number JP20he0922003 .
Conflicts of interest: There are no conflicts of interest to declare.
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