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Risk factors for nosocomial methicillin resistant Staphylococcus aureus (MRSA) colonization in a neonatal intensive care unit: A Case-control study

Published:April 30, 2021DOI:https://doi.org/10.1016/j.ajic.2021.04.082

      Highlights

      • Persistently circulating MRSA clone in NICU.
      • Risk factors for MRSA colonization, independent of length of stay & gestational age.
      • Colonization pressure, lower ATP pass rate are associated with acquisition of colonization.
      • Higher acuity of care is also associated with acquisition of colonization.
      • In a multivariable model, only colonization pressure was significantly associated.

      Aim

      To determine risk factors for MRSA colonization in a Level IV Neonatal Intensive Care Unit (NICU) independent of length of stay and gestational age in the context of a persistently circulating MRSA clone.

      Design

      Retrospective matched case-control study.

      Setting

      Level IV NICU

      Patients

      Infants admitted between April 4,2017- March 31,2018.

      Methods

      Based on weekly surveillance cultures, infants who acquired MRSA were matched 1:1 with MRSA-negative control infants by duration of exposure (length of stay) and gestational age to determine risk factors for acquisition.

      Results

      Fifty case infants were matched with controls. Isolates from 45 of the 50 cases were mupirocin-resistant and related by pulse-field gel electrophoresis. On matched univariable analysis, the following were significantly associated with a risk for MRSA acquisition: 1.Bed location in the acute area(P = 0.03), 2.Requirement of any level of respiratory support during the week prior to MRSA detection(P = 0.04), 3.Higher ATP pass rate (a measure of effectiveness of cleaning) during the week of and week prior(P = 0.01), 4.Higher MRSA colonization pressure during the week of and week prior(P< 0.0001), 5.Not having a hearing test during the time between the previous negative culture and MRSA acquisition(P = 0.01). A multivariable conditional logistic regression model (that excluded ATP pass rate) found that only colonization pressure was associated with acquisition of MRSA colonization.

      Conclusions

      In an outbreak setting, MRSA colonization pressure is significantly associated with MRSA acquisition in the NICU independent of length of stay and gestational age.

      Key Words

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