- •A clonal MRSA can cause a prolonged outbreak in NICU with quiescent periods
- •Whole genome sequencing is a valuable tool for analyzing an MRSA outbreak
- •Healthcare personnel can be implicated in MRSA transmission to infants
- •Room location within a NICU can be associated with MRSA transmission
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to American Journal of Infection Control
- Device-associated infections among neonatal intensive care unit patients: incidence and associated pathogens reported to the National Healthcare Safely Network, 2006-2008.Infect Control Hosp Epidemiol. 2012; 33: 1200-1206
- Antimicrobial-resistant pathogens associated with healthcare-associated infections: Summary of data reported to the National Healthcare Safety Network, 2015-2017.Infect Control Hosp Epidemiol. 2020; 41: 19-30
- Methicillin-resistant and susceptible Staphylococcus aureus bacteremia and meningitis in preterm infants.Pediatrics. 2012; 129: e914-e922
- Neurodevelopmental outcomes of very low birth weight infants with neonatal sepsis: systematic review and meta-analysis.J Perinatol. 2013; 33: 558-564
- Community-genotype strains of methicillin-resistant Staphylococcus aureus with high-level mupirocin resistance in a neonatal intensive care unit.Early Human Development. 2013; 89: 661-665
- The effect of routine surveillance and decolonization on the rate of Staphylococcus aureus infections in a level iv neonatal intensive care unit.J Perinatol. 2020; 40: 1644-1651
- Revisiting the WHO "How to Handrub" hand hygiene technique: fingertips first?.Infect Control Hosp Epidemiol. 2017; 38: 230-233
- Risk factors for nosocomial methicillin resistant Staphylococcus aureus (MRSA) colonization in a neonatal intensive care unit: a case-control study.Am J Infect Control. 2021; (in press)
- A complete genome screening program of clinical methicillin-resistant Staphylococcus aureus isolates identifies the origin and progression of a neonatal intensive care unit outbreak.J Clin Microbiol. 2019; 57 (e01261-19)
- Whole-genome sequencing for methicillin-resistant Staphylococcus aureus (MRSA) outbreak investigation in a neonatal intensive care unit.Infect Control Hosp Epidemiol. 2018; 39: 1412-1418
- Whole-genome sequencing for analysis of an outbreak of methicillin-resistant Staphylococcus aureus: a descriptive study.Lancet Infect Dis. 2013; 13: 130-136
- An outbreak of meticillin-resistant Staphylococcus aureus colonization in a neonatal intensive care unit: use of a case control study to investigate and control it and lessons learnt.J Hospital Infect. 2019; 103 (35e43)
- Prevention of infections with multidrug-resistant (MDR) organisms.in: Bryant KA Guzman-Cottrill JA Handbook of Pediatric Infection Prevention and Control. Oxford University Press, NY2019: 141-172
- Management of outbreaks of methicillin-resistant Staphylococcus aureus infection in the neonatal intensive care unit: a consensus statement.Infect Control Hosp Epidemiol. 2006; 27: 139-145
- Whole-genome sequencing for outbreak investigations of methicillin-resistant Staphylococcus aureus in the neonatal intensive care unit: time for routine practice?.Infect Control Hosp Epidemiol. 2015; 36: 777-785
- Spatial and environmental correlates of organism colonization and infection in the neonatal intensive care unit.J Perinatol. 2018; 38: 567-573
- Spa typing of Staphylococcus aureus in a neonatal intensive care unit during routine surveillance.J Pediatric Infect Dis Soc. 2021; 10: 766-773
- Impact of decolonization on methicillin-resistant Staphylococcus aureus transmission and infection in a neonatal intensive care unit.Infect Control Hosp Epidemiol. 2019; 40: 1123-1127
Conflicts of interest: None to report.
Previous submission of abstract: Rubin LG, Beachy J, Uhlemann A-C, Annavajhala M, Balamohan A, Jendresky L. Prolonged Outbreak of Clonal, Mupirocin-resistant Methicillin-resistant Staphylococcus aureus (MRSA) in a Neonatal Intensive Care Unit (NICU): association with Personnel and Possible Environmental Reservoir, analysed using Whole Genome Sequencing (WGS). Pediatric Academic Societies (PAS) 2020 Meeting, May 2-5, 2020, in Philadelphia, PA (accepted but not presented due to meeting cancellation related to COVID-19 pandemic).
Abbreviated title: NICU outbreak of mupirocin-resistant MRSA