- •Adherence to blood culture bundle can reduce contamination rate.
- •Less contamination when collected from superficial veins of the cubital fossa.
- •Using chlorhexidine alcohol reduced contamination.
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to American Journal of Infection Control
- Current approaches to the diagnosis of bacterial and fungal bloodstream infections in the intensive care unit.Crit Care Med. 2012; 40: 3277-3282
- The clinical and prognostic importance of positive blood cultures in adults.Am J Med. 2010; 123: 819-828
- Coagulase-negative staphylococci: role as pathogens.Annu Rev Med. 1999; 50: 223-236
- Nosocomial bacteremia: clinical significance of a single blood culture positive for coagulase-negative staphylococci.Infect Control Hosp Epidemiol. 2005; 26: 697-702
- Differentiating culture samples representing coagulase-negative staphylococcal bacteremia from those representing contamination by use of time-to-positivity and quantitative blood culture methods.J Clin Microbiol. 2009; 47: 3255-3260
- Multidisciplinary team review of best practices for collection and handling of blood cultures to determine effective interventions for increasing the yield of true-positive bacteremias, reducing contamination, and eliminating false-positive central line-associated bloodstream infections.Am J Infect Control. 2015; 43: 1222-1237
- Contaminant blood cultures and resource utilization. The true consequences of false-positive results.Jama. 1991; 265: 365-369
- Economic health care costs of blood culture contamination: a systematic review.Am J Infect Control. 2019; 47: 963-967
- An alternative strategy for studying adverse events in medical care.Lancet (London, England). 1997; 349: 309-313
- Practical guidance for clinical microbiology laboratories: a comprehensive update on the problem of blood culture contamination and a discussion of methods for addressing the problem.Clin Microbiol Rev. 2019; : 33
- Estimated clinical and economic impact through use of a novel blood collection device to reduce blood culture contamination in the emergency department: a cost-benefit analysis.J Clin Microbiol. 2019; 57
- Reducing blood culture contamination using an initial specimen diversion device.Am J Infect Control. 2019; 47: 822-826
- Evaluation of an Initial Specimen Diversion Device (ISDD) on Rates of Blood Culture Contamination in the Emergency Department.Kansas J Med. 2021; 14: 73-76
- Effectiveness of practices to reduce blood culture contamination: a Laboratory Medicine Best Practices systematic review and meta-analysis.Clin Biochem. 2012; 45: 999-1011
- Cost analysis of strategies to reduce blood culture contamination in the emergency department: sterile collection kits and phlebotomy teams.Infect Control Hosp Epidemiol. 2014; 35: 1021-1028
- Blood culture quality improvement: a College of American Pathologists Q-Probes study involving 909 institutions and 289 572 blood culture sets.Arch Pathol Lab Med. 1996; 120: 999-1002
- Trends in blood culture contamination: a College of American Pathologists Q-Tracks study of 356 institutions.Arch Pathol Lab Med. 2005; 129: 1222-1225
- Solitary blood cultures: a College of American Pathologists Q-probes study of 132,778 blood culture sets in 333 small hospitals.Arch Pathol Lab Med. 2001; 125: 1290-1294
- A simplified blood culture sampling protocol for reducing contamination and costs: a randomized controlled trial.Clin Microbiol Infect. 2020; 26: 470-474
- Peripheral blood culture contamination in adults and venepuncture technique: prospective cohort study.J Clin Pathol. 2008; 61: 509-513
- Microbial ecology of the skin.Annu Rev Microbiol. 1988; 42: 441-464
- Skin antiseptics in venous puncture-site disinfection for prevention of blood culture contamination: systematic review with meta-analysis.J Hosp Infect. 2011; 77: 223-232
- Chlorhexidine compared with povidone-iodine as skin preparation before blood culture. A randomized, controlled trial.Ann Intern Med. 1999; 131: 834-837
- The clinical significance of positive blood cultures in the 1990s: a prospective comprehensive evaluation of the microbiology, epidemiology, and outcome of bacteremia and fungemia in adults.Clin Inf. dis. 1997; 24: 584-602
- Sites of blood collection and topical antiseptics associated with contaminated cultures: prospective observational study.Sci Rep. 2021; 11: 6211
Conflicts of interest: The authors declare that they have no conflicts of interest.
Author contributions: All authors met the ICMJE authorship criteria. Fumiko Kawanishi and Kyohei Yoshioka were responsible for the organization and coordination of the study. Kenta Minami and Tomoyuki Yamada developed the study design and held responsibility for the data analysis. Akira Ukimura and Taku Ogawa administered this project. All authors contributed to the writing of the final manuscript and to the management or administration of the study.