Highlights
- •About 5% betadine solutions and silver colloidal gel (Ag-gel), is more effective than the individual materials in inhibiting the growth of both Gram negative and Gram positive bacteria.
- •Use of silver gel allows for the use of lower concentration of betadine to eliminate bacteria
- •The combination of betadine and silver gel may be applied to other clinical scenarios such as burn wounds.
Introduction
Betadine (Povidone-Iodine) solution is a topically applied antiseptic, which has been
used routinely used in wound care and general surgery to prevent skin and wound infections.
However, several studies have documented the ineffectiveness of betadine. Other topical
antimicrobial dressings, including those that contain silver, have been used in the
management of infected wounds. The present study was undertaken to determine if the
combination of 5% betadine solution and silver colloidal gel (Ag-gel) is more effective
than either substance alone in inhibiting the growth gram-negative and gram-positive
bacteria.
Methods
The effectiveness of 5% betadine solution and Ag-gel as anti-microbial agents were
assessed using both colony forming unit (CFU) assay and confocal laser scanning microscopy
(CLSM).
Results
Ag-gel showed complete inhibition on all the bacteria species examined except the
Klebsiella pneumoniae clinical isolate (CL) strain while 5% betadine concentrations did not completely
kill any of the tested bacteria. In contrast, K. pneumoniae was completely eliminated in the presence of both 5% betadine solution and Ag-gel
together. The CLSM showed similar findings to the CFU results examining the 5% betadine
solution and Ag-gel combination.
Conclusions
This study demonstrated that while the individual treatments using either 5% betadine
solution and Ag-gel alone were infective antimicrobial agents, the combination of
5% betadine solution and Ag-gel was superior at eliminating all tested bacteria, including
K. pneumoniae CL.
Keywords
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Article Info
Publication History
Published online: April 15, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Conflict of Interest: The authors whose names are listed immediately below certify that they have NO affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.
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© 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
