Evaluating a Continuously Active Disinfectant Wipe on High Touch Surfaces in Rooms of Patients with Multidrug-Resistant Organisms (MDROs)

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      Recontamination of the patient's environment occurs quickly after thorough disinfection and could contribute to the transmission of healthcare-associated infections. We aimed to determine whether a continuous active disinfectant wipe (CADW) could provide sustained disinfection for rooms of MDRO carriers.


      We sampled a small number of rooms of MDRO carriers in an academic hospital and nursing home setting. Rooms underwent routine cleaning by environmental services immediately followed by additional high-touch cleaning by Infection Preventionists with 1) routine disinfecting wipes (RDW) and 2) CADW on separate days. Five pre-specified high-touch surfaces were cultured with pre-moistened spongesicles 23 hours post-cleaning in four hospital rooms, eight hours post-cleaning in two hospital rooms, and eight hours post-cleaning in three nursing home rooms. Spongesicles were processed at a CLIA-certified laboratory with 40cc of phosphate-buffered saline, stomaching for one minute, centrifuging the liquid, reconstituting in 5cc of fluid, and plating per CLSI standards.


      At 23 hours, three of four rooms had MDRO contamination after RDW (two MRSA and one C. auris), with same findings after CADW. Six RDW objects were positive for MRSA and two for C. auris. Five CADW objects were positive for MRSA and one for C. auris. At 8 hours, four of five hospital/nursing home rooms had MDRO contamination after RDW (two MRSA, one C. auris, one VRE) compared to three of five rooms after CADW (2 MRSA and 1 C. auris). Six RDW objects were positive for MRSA, two for C. auris, and one for VRE. Six CADW objects were positive for MRSA and one for C. auris.


      In this exploratory analysis, CADW did not provide a clinically meaningful reduction in MDRO contamination of high-touch surfaces at either 8 or 23 hours compared to RDW. Ongoing efforts to demonstrate effective and sustained surface antimicrobial activity to reduce fomites is needed.
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