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Background
Recontamination of the patient's environment occurs quickly after thorough disinfection
and could contribute to the transmission of healthcare-associated infections. We aimed
to determine whether a continuous active disinfectant wipe (CADW) could provide sustained
disinfection for rooms of MDRO carriers.
Methods
We sampled a small number of rooms of MDRO carriers in an academic hospital and nursing
home setting. Rooms underwent routine cleaning by environmental services immediately
followed by additional high-touch cleaning by Infection Preventionists with 1) routine
disinfecting wipes (RDW) and 2) CADW on separate days. Five pre-specified high-touch
surfaces were cultured with pre-moistened spongesicles 23 hours post-cleaning in four
hospital rooms, eight hours post-cleaning in two hospital rooms, and eight hours post-cleaning
in three nursing home rooms. Spongesicles were processed at a CLIA-certified laboratory
with 40cc of phosphate-buffered saline, stomaching for one minute, centrifuging the
liquid, reconstituting in 5cc of fluid, and plating per CLSI standards.
Results
At 23 hours, three of four rooms had MDRO contamination after RDW (two MRSA and one
C. auris), with same findings after CADW. Six RDW objects were positive for MRSA and
two for C. auris. Five CADW objects were positive for MRSA and one for C. auris. At
8 hours, four of five hospital/nursing home rooms had MDRO contamination after RDW
(two MRSA, one C. auris, one VRE) compared to three of five rooms after CADW (2 MRSA
and 1 C. auris). Six RDW objects were positive for MRSA, two for C. auris, and one
for VRE. Six CADW objects were positive for MRSA and one for C. auris.
Conclusions
In this exploratory analysis, CADW did not provide a clinically meaningful reduction
in MDRO contamination of high-touch surfaces at either 8 or 23 hours compared to RDW.
Ongoing efforts to demonstrate effective and sustained surface antimicrobial activity
to reduce fomites is needed.
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Copyright
© 2022 Published by Elsevier Inc.
