Advertisement

Trends in Clostridioides difficile infection across a public health hospital system in New York City 2019-2021: A cautionary note

      Highlights

      • Healthcare facility-onset Clostridioides difficile infection across an 11-hospital system rose after the spring of 2020.
      • The reason for the increase in C. difficile infections is multifactorial.
      • The increase in C. difficile during the spring of 2020 correlated with an increase in cephalosporin use.
      Contrary to national reports, rates of healthcare facility-onset Clostridioides difficile infection across an 11-hospital system rose after the spring of 2020, when New York City was the epicenter for the COVID-19 pandemic. Antibiotic pressure from an escalation in cephalosporin usage correlated with this increase. The majority of cases of Clostridioides difficile were in patients without COVID-19, suggesting the pandemic has adversely impacted the healthcare of other inpatients.

      Key words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to American Journal of Infection Control
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Rose AN
        • Baggs J
        • Wolford H
        • et al.
        Trends in antibiotic use in United States hospitals during the coronavirus disease 2019 pandemic.
        Open Forum Infect Dis. 2021; 8: ofab236
        • Weiner-Lastinger LM
        • Pattabiraman V
        • Konnor RY
        • et al.
        The impact of coronavirus disease 2019 (COVID-19) on healthcare-associated infections in 2020: a summary of data reported to the National Healthcare Safety Network.
        Infect Control Hosp Epidemiol. 2022; 43: 12-25
        • Baker MA
        • Sands KE
        • Huang SS
        • et al.
        The impact of COVID-19 on healthcare-associated infections.
        Clin Infect Dis. 2021;
        • Episcopia B
        • Gupta A
        • Fornek M
        • et al.
        Trends in healthcare facility-onset Clostridioides difficile infection and the impact of testing schemes in an acute care hospital system in New York City, 2016-2019.
        Am J Infect Control. 2021; 49: 1262-1266
        • Young EH
        • Beck E
        • Ford D
        • et al.
        Increased prevalence of Clostridioides difficile infection during the COVID-19 pandemic among hospitalized veterans in south Texas, USA.
        Open Forum Infect Dis. 2021; 8: 476-477
        • Fleisher LA
        • Schreiber M
        • Cardo D
        • Srinivasan A.
        Health care safety during the pandemic and beyond- building a system that endures resilience.
        N Eng J Med. 2022; 386: 609-611
        • Nguyen NT
        • Chinn J
        • Nahmias J
        • et al.
        Outcomes and mortality among adults hospitalized with COVID-19 at US medical centers.
        JAMA Network Open. 2021; 4e210417
        • Vekaria B
        • Overton C
        • Wisniowski A
        • et al.
        Hospital length of stay for COVID-19 patients: data-driven methods for forward planning.
        BMC Infect Dis. 2021; 21: 700
        • Owens Jr, RC
        • Donskey CJ
        • Gaynes RP
        • Loo VG
        • Muto CA
        Antimicrobial-associated risk factors for Clostridium difficile infection.
        Clin Infect Dis. 2008; 46: S19-S31
        • Guerrero DM
        • Becker JC
        • Eckstein EC
        • et al.
        Asymptomatic carriage of toxigenic Clostridium difficile by hospitalized patients.
        J Hosp Infect. 2013; 85: 155-158