Highlights
- •The J-SIPHE system enabled multicenter analysis of antibiotic use and resistance.
- •Carbapenem use correlated with carbapenem-resistant P. aeruginosa occurrence.
- •Quinolone use correlated with fluoroquinolone-resistant E. coli occurrence.
Abstract
Background
The Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE)
system aggregates information related to antimicrobial resistance (AMR) measures in
participating medical institutions nationwide and is intended to be used for promotion
of AMR measures in participating facilities and their communities. This multicenter
study aimed to determine the usefulness of the J-SIPHE system for evaluating the correlation
between antibiotic use and antibiotic resistance in Hokkaido, Japan.
Methods
Data on antibiotic use and detection rate of major resistant Gram-negative bacteria
at 19 hospitals in 2020 were collected from the J-SIPHE system, and data correlations
were analyzed using JMP Pro.
Results
The detection rate of carbapenem-resistant Pseudomonas aeruginosa was significantly positively correlated with carbapenem use (Spearman's ρ = 0.551;
P = .015). There were significant positive correlations between the detection rate
of fluoroquinolone-resistant Escherichia coli and the use of piperacillin/tazobactam, carbapenems, and quinolones [ρ = 0.518 (P = .023), ρ = 0.76 (P < .001), and ρ = 0.502 (P = .029), respectively].
Conclusions
This is the first multicenter study to investigate the correlation between antibiotic
use and antibiotic resistance using the J-SIPHE system. The results suggest that using
this system may be beneficial for promoting AMR measures.
Key Words
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to American Journal of Infection ControlAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- An institutional review of antimicrobial stewardship interventions.J Glob Antimicrob Resist. 2016; 6: 75-77
- The relationship between antimicrobial resistance and patient outcomes: mortality, length of hospital stay, and health care costs.Clin Infect Dis. 2006; 42: S82-S89
- Hospital and societal costs of antimicrobial-resistant infections in a Chicago teaching hospital: implications for antibiotic stewardship.Clin Infect Dis. 2009; 49: 1175-1184
- Antimicrobial resistance surveillance and prediction of Gram-negative bacteria based on antimicrobial consumption in a hospital setting: a 15-year retrospective study.Medicine. 2019; 98: e17157
- Influence of antimicrobial consumption on gram-negative bacteria in inpatients receiving antimicrobial resistance therapy from 2008–2013 at a tertiary hospital in Shanghai, China.Am J Infect Control. 2015; 43: 358-364
- Temporal association between carbapenems usage and antimicrobial resistance in gram-negative bacteria at a tertiary hospital in Nanjing, China.Diagn Microbiol Infect Dis. 2020; 98115083
- Relationships between antimicrobial use and antimicrobial resistance in Gram-negative bacteria causing nosocomial infections from 1991–2003 at a university hospital in Taiwan.Int J Antimicrob Agents. 2005; 26: 463-472
- Correlation between antibiotic consumption and resistance of Gram-negative bacteria causing healthcare-associated infections at a university hospital in Taiwan from 2000 to 2009.J Antimicrob Chemother. 2011; 66: 1374-1382
- Antimicrobial consumption and resistance in five gram-negative bacterial species in a hospital from 2003 to 2011.J Microbiol Immunol Infect. 2015; 48: 647-654
- Correlation between antimicrobial consumption and the prevalence of carbapenem-resistant Escherichia coli and carbapenem-resistant Klebsiella pneumoniae at a university hospital in Thailand.J Clin Pharm Ther. 2019; 44: 292-299
- Correlation between levofloxacin consumption and the incidence of nosocomial infections due to fluoroquinolone-resistant Escherichia coli.J Microbiol Immunol Infect. 2016; 49: 424-429
- Surveillance and correlation of antimicrobial usage and resistance of Pseudomonas aeruginosa: a hospital population-based study.PLOS ONE. 2013; 8: e78604
National Center for Global Health and Medicine, AMR Clinical Reference Center. Tokyo, Japan Surveillance for Infection Prevention and Healthcare Epidemiology (J-SIPHE) Annual Report 2019. NCGM, AMRCRC. Accessed October 31, 2021. https://j-siphe.ncgm.go.jp/files/JSIPHE_AnnualReport_2019en.pdf.
World Health Organization (WHO). Global Action Plan on Antimicrobial Resistance. Geneva: WHO. Accessed October 31, 2021. http://apps.who.int/iris/bitstream/handle/10665/193736/9789241509763_eng.pdf.
The Government of Japan. National Action Plan on Antimicrobial Resistance (AMR). The Government of Tokyo, Japan; 2016–2020. Accessed October 31, 2021. https://www.mhlw.go.jp/file/06-Seisakujouhou-10900000-Kenkoukyoku/0000138942.pdf.
WHO Collaborating Centre for Drug Statistics Methodology. Guidelines for ATC Classification and DDD Assignments. Oslo: WHO Collaborating Centre for Drug Statistics Methodology; 2020. Accessed October 31, 2021. https://www.whocc.no/atc_ddd_index/.
- Performance Standards for Antimicrobial Susceptibility Testing: Twenty-First Informational Supplement M100-S21.CLSI, Wayne, PA2011
- ATB-RAISIN network steering committee. Higher third-generation cephalosporin prescription proportion is associated with lower probability of reducing carbapenem use: a nationwide retrospective study.Antimicrob Resist Infect Control. 2018; 7: 11
- Association between antibiotic consumption and the rate of carbapenem-resistant Gram-negative bacteria from China based on 153 tertiary hospitals data in 2014.Antimicrob Resist Infect Control. 2018; 7: 137
- Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study.J Clin Pharm Ther. 2016; 41: 532-537
- Consumption of imipenem correlates with beta-lactam resistance in Pseudomonas aeruginosa.Antimicrob Agents Chemother. 2002; 46: 2920-2925
- Correlation between antibiotic consumption and resistance of bloodstream bacteria in a University Hospital in North Eastern Italy, 2008–2014.Infection. 2017; 45: 459-467
- Association between the rate of fluoroquinolones-resistant gram-negative bacteria and antibiotic consumption from China based on 145 tertiary hospitals data in 2014.BMC Infect Dis. 2020; 20: 269
- Estudio de Prevalencia de las Infecciones Nosocomiales en España (EPINE) Working Group. Trends in yearly prevalence of third-generation cephalosporin and fluoroquinolone resistant Enterobacteriaceae infections and antimicrobial use in Spanish hospitals, Spain, 1999 to 2010.Euro Surveill. 2011; 16: 19983
- Antibiotic consumption and its influence on the resistance in Enterobacteriaceae.BMC Res Notes. 2014; 7: 454
- Dramatic increase of third-generation cephalosporin-resistant E. coli in German intensive care units: secular trends in antibiotic drug use and bacterial resistance, 2001 to 2008.Crit Care. 2010; 14: R113
- Implementing an antibiotic stewardship program: guidelines by the infectious diseases society of America and the society for healthcare epidemiology of America.Clin Infect Dis. 2016; 62: e51-e77
- Antimicrobial stewardship programs: appropriate measures and metrics to study their impact.Curr Treat Options Infect Dis. 2014; 6: 101-112
Article Info
Publication History
Published online: June 04, 2022
Publication stage
In Press Journal Pre-ProofFootnotes
Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Conflicts of interest: All authors have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Identification
Copyright
© 2022 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.
