Prevalence of Methicillin-Resistant Staphylococcus aureus carriage among Healthcare Workers in South Asia in non-outbreak settings: a systematic review and meta-analysis


      • Methicillin-Resistant Staphylococcus aureus (MRSA) causes a fatal and invasive form of the disease
      • Healthcare Workers(HCWs) are at greater risk of colonization with MRSA
      • HCWs cause transmission of MRSA within a hospital setting
      • Prevalence of MRSA carriage among HCWs is slightly higher in South Asia than in European and American Nation
      • Our study summarized the overall MRSA carriage rate of 9.23% (95%CI; 6.50%, 12.35%) among HCWs in SAARC nations, with nurses having higher odds of getting infected



      This study aimed to estimate the pooled prevalence and sub-group-specific prevalence of Methicillin-resistant Staphylococcus aureus (MRSA) carrier rate among Healthcare Workers (HCWs) in South Asia.


      We considered prospective and cross-sectional studies published in the English language with participants ≥ 50 by searching different electronic databases to locate the relevant articles that reported the epidemiology of MRSA. The participants were healthy South Asian nationality HCWs (asymptomatic for any infectious disease) of any age and gender with a definitive diagnosis of MRSA carriage. The result was synthesized for the pooled prevalence of MRSA carriers among HCWs using 95% confidence interval (CI) with DerSimonian and Laird random-effects models.


      The pooled prevalence of MRSA carriage among HCWs was 9.23% (95%CI; 6.50%, 12.35%) with a range from 0.67% to 36.06%. The prevalence in India, Nepal, Pakistan, Sri Lanka, and Bangladesh was 5.65% (95%CI; 3.65%, 8.03%), 8.83% (95%CI; 6.77%, 11.11%), 17.20% (95%CI; 10.70%, 24.85%), 22.56% (95%CI; 4.93%, 47.83%) and 4.93% (95%CI; 1.88%, 9.20%) respectively. The pooled prevalence of MRSA carriage among nurses and doctors was 8.90% (95%CI; 6.00%, 12.24%) and 6.53% (95%CI; 3.63%, 10.06%) respectively.


      The findings from our study suggests that if the propagation of MRSA continues, then it can lead to a situation of an outbreak. Hence, proper preventive measures are to be adopted to prevent this outbreak.

      Graphical Abstract


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