- •E. coli sequence type 131 accounts for many extraintestinal E. coli infections.
- •315 urine isolates from two medical centers in Minneapolis and Boston were compared.
- •Isolates exhibited predominantly B2 phylogenetic group and comparable ST131 prevalence.
- •Virulence genotypes varied significantly in relation to center and ST131 status.
- •The emerging C1-M27 subclone occurred uniquely among 6% of Boston isolates.
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Funding/Support: This research was supported in part by Office of Research and Development, Department of Veteran Affairs , grant # 2I01CX000920-04 (J.R.J).
Conflicts of interest: Elizabeth B. Hirsch has received research funding from Merck and advisory board honorarium from Melinta, MeMed, and Merck. James R. Johnson has had research grants and/or consultancies involving Achaogen, Allergan, Crucell/Janssen, Melinta, Merck, Shionogi, Syntiron, and Tetraphase, and has patent applications for tests to detect specific E. coli strains. All other authors declare no conflicts of interest.