Impact of a change in universal gloving protocol on rates of central line-related bloodstream infection, Clostridioides difficile, and vancomycin-resistant Enterococcus

Published:October 13, 2022DOI:


      • CLABSI, C. difficile, and VRE were assessed after removal of universal gloving.
      • Discontinuation of universal gloving did not impact rates of these infection.
      • Adherence to hand hygiene was similar throughout.


      In this retrospective cohort of adult hematology-oncology and transplant patients, discontinuation of universal gloving did not result in significant changes in rates of central line-associated bloodstream infection, Clostridioides difficile infection, or vancomycin-resistant Enterococcus colonization. Active surveillance and subsequent isolation may be a viable alternative strategy to universal precautions.

      Key Words

      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'


      Subscribe to American Journal of Infection Control
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect


        • Jackson SS
        • Thom KA
        • Magder LS
        • et al.
        Patient contact is the main risk factor for vancomycin-resistant Enterococcus contamination of healthcare workers’ gloves and gowns in the intensive care unit.
        Infect Control Hosp Epidemiol. 2018; 39: 1063-1067
        • Hayden MK
        • Blom DW
        • Lyle EA
        • Moore CG
        • Weinstein RA.
        Risk of hand or glove contamination after contact with patients colonized with vancomycin-resistant enterococcus or the colonized patients’ environment.
        Infect Control Hosp Epidemiol. 2008; 29: 149-154
        • Harris AD
        • Pineles L
        • Belton B
        • et al.
        Universal glove and gown use and acquisition of antibiotic-resistant bacteria in the ICU: a randomized trial.
        JAMA. 2013; 310: 1571-1580
        • Yin J
        • Schweizer ML
        • Herwaldt LA
        • Pottinger JM
        • Perencevich EN.
        Benefits of universal gloving on hospital-acquired infections in acute care pediatric units.
        Pediatrics. 2013; 131: e1515-e1520
        • Chang NCN
        • Kates AE
        • Ward MA
        • et al.
        Association between universal gloving and healthcare-associated infections: a systematic literature review and meta-analysis.
        Infect Control Hosp Epidemiol. 2019; 40: 755-760
        • Bearman G
        • Rosato AE
        • Duane TM
        • et al.
        Trial of universal gloving with emollient-impregnated gloves to promote skin health and prevent the transmission of multidrug-resistant organisms in a surgical intensive care unit.
        Infect Control Hosp Epidemiol. 2010; 31: 491-497
        • Morgan DJ
        • Dubberke ER
        • Hink T
        • et al.
        The impact of universal glove and gown use on clostridioides difficile acquisition: a cluster-randomized trial.
        Clin Infect Dis. 2022; (Published online July 1)
        • Williams C
        • McGraw P
        • Schneck EE
        • et al.
        Impact of universal gowning and gloving on health care worker clothing contamination.
        Infect Control Hosp Epidemiol. 2015; 36: 431-437
        • Prasad P
        • Brown L
        • Ma S
        • et al.
        If the glove fits”: Hospital-wide universal gloving is associated with improved hand hygiene and may reduce Clostridioides difficile infection.
        Infect Control Hosp Epidemiol. 2021; 42: 1351-1355
        • Hachem R
        • Graviss L
        • Hanna H
        • et al.
        Impact of surveillance for vancomycin-resistant enterococci on controlling a bloodstream outbreak among patients with hematologic malignancy.
        Infect Control Hosp Epidemiol. 2004; 25: 391-394
        • Perencevich EN
        • Fisman DN
        • Lipsitch M
        • Harris AD
        • Morris Jr., JG
        • Smith DL
        Projected benefits of active surveillance for vancomycin-resistant enterococci in intensive care units.
        Clin Infect Dis. 2004; 38: 1108-1115
        • Bellini C
        • Eder M
        • Senn L
        • et al.
        Providing care to patients in contact isolation: is the systematic use of gloves still indicated?.
        Swiss Med Wkly. 2022; 152: w30110