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Efficacy of Chlorhexidine in Advanced Penetration Technology formulation in decolonizing the skin using Candida auris skin colonization mouse model

Published:November 20, 2022DOI:https://doi.org/10.1016/j.ajic.2022.11.010

      Highlights

      • Candida auris can cause multiple outbreak due to its ability to colonize the skin.
      • Chlorhexidine Next Gen™ (CHG) is a novel formulation for skin decolonization based on the Advanced Performance Technology (APT) with dual effects on microbial cell wall.
      • APT-CH formulation may also have inhibitory activity against C. auris biofilms due to enhanced skin penetration.

      Abstract

      The incidence of Candida auris, an emerging multidrug resistant fungal species, is increasing. The ability of this yeast to colonize the human skin could lead to infections. Thus, identifying agents to reduce the skin fungal burden is critical. In this study, using a murine skin model, we evaluated the efficacy of chlorhexidine formulated in a new Advanced Penetration Technology formulation (APT-CH) and showed that this formulation was significantly more effective than untreated controls. Additionally, the APT-CH formulation was more effective than vehicle-treated animals albeit not statistically significant. This data suggests that the APT-CH formulation may have utility in skin colonization. Additional studies are warranted.

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